Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production

被引：29

作者：

Yang, Bing-You ^{[1
]}

Guo, Rui ^{[1
]}

Li, Ting ^{[1
]}

Liu, Yan ^{[1
]}

Wang, Chang-Fu ^{[1
]}

Shu, Zun-Peng ^{[1
]}

Wang, Zhi-Bin ^{[1
]}

Zhang, Jing ^{[1
]}

Xia, Yong-Gang ^{[1
]}

Jiang, Hai ^{[1
]}

Wang, Qiu-Hong ^{[1
]}

Kuang, Hai-Xue ^{[1
]}

机构：

[1] Heilongjiang Univ Chinese Med, Key Lab Chinese Mat Med, Minist Educ, Harbin 150040, Peoples R China

来源：

MOLECULES | 2014年 / 19卷 / 04期

关键词：

Datura metel L; withanolides; dmetelins; NO inhibition; FLOWER; GLUCOSIDES;

D O I：

10.3390/molecules19044548

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four new withanolides named dmetelins A-D (compounds 1-4), along with the known compound 7 alpha,27-dihydroxy-1-oxo-witha-2,5,24-trienolide (5) were isolated from the leaves of Datura metel L. (Solanaceae). Their structures were elucidated on the basis of detailed analysis of 1D and 2D NMR and mass spectrometry data. All the compounds were evaluated for their inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells. Compounds 1, 4 and 5 showed significant inhibitory activities, and compounds 2 and 3 showed moderate inhibitory activities with IC50 values of 17.8, 11.6, 14.9, 33.3 and 28.6 mu M, respectively.

引用

页码：4548 / 4559

页数：12

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