Clinical characteristics of chemotherapy-induced alopecia in childhood

被引：24

作者：

Choi, Mira ^{[1
]}

Kim, Min Sun ^{[2
,3
]}

Park, Song Youn ^{[1
]}

Park, Gyeong Hun ^{[4
]}

Jo, Seong Jin ^{[1
]}

Cho, Kwang Hyun ^{[1
]}

Lee, Ji Won ^{[2
,3
]}

Park, Kyung Duk ^{[2
,3
]}

Shin, Hee Young ^{[2
,3
]}

Kang, Hyoung Jin ^{[2
,3
]}

Kwon, Ohsang ^{[1
,5
,6
]}

机构：

[1] Seoul Natl Univ, Coll Med, Dept Dermatol, Seoul 110744, South Korea

[2] Seoul Natl Univ, Coll Med, Dept Pediat, Div Hematol Oncol, Seoul 110744, South Korea

[3] Seoul Natl Univ, Coll Med, Canc Res Inst, Seoul 110744, South Korea

[4] Hallym Univ, Coll Med, Dongtan Sacred Heart Hosp, Dept Dermatol, Hwaseong, South Korea

[5] Seoul Natl Univ, Inst Human Environm Interface Biol, Seoul 110744, South Korea

[6] Seoul Natl Univ Hosp, Biomed Res Inst, Lab Cutaneous Aging & Hair Res, Seoul, South Korea

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2014年 / 70卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

alopecia; chemotherapy; chemotherapy-induced alopecia; childhood; hematopoietic stem cell transplantation; permanent; thiotepa; BONE-MARROW-TRANSPLANTATION; STEM-CELL TRANSPLANTATION; HAIR LOSS; PERMANENT ALOPECIA; CYCLOPHOSPHAMIDE; REGROWTH;

D O I：

10.1016/j.jaad.2013.10.034

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: Chemotherapy-induced alopecia (CIA) is a frequent complication in patients with cancer. There are an increasing number of reports of permanent CIA. Objective: We investigated the clinical characteristics of CIA, including permanent CIA in childhood. Methods: We collected data on 159 pediatric patients who had undergone high-dose conditioning chemotherapy followed by hematopoietic stem cell transplantation and 167 control subjects, using a questionnaire, medical record reviews, and phototrichograms. Results: Alopecia began at 1.5 +/- 1.4 months and was sustained until 2.2 +/- 1.6 months after chemotherapy initiation. Hair regrowth started 2.6 +/- 1.6 months after chemotherapy ceased and lasted for 7.3 +/- 4.9 months. The mean hair density and thickness were 198.3 +/- 47.4/cm(2) and 76.3 +/- 18.4 mu m in the patient group and 229.+/- 6 34.5/cm(2) and 79.5 +/- 12.4 mu m in the control group, respectively (both, P < .001). In all, 19 (12%) patients experienced permanent CIA. Thiotepa use was identified as a significant risk factor for permanent CIA (odds ratio 7.57, P = .002). Limitations: Cross-sectional study in a single-center is a limitation. Conclusion: CIA is common in pediatric patients. Use of thiotepa is strongly associated with permanent CIA.

引用

页码：499 / 505

页数：7

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