Glucocorticoid-induced apoptosis and cellular mechanisms of myopathy

被引:43
作者
Dirks-Naylor, Amie J. [1 ]
Griffiths, Carrie L. [1 ]
机构
[1] Wingate Univ, Sch Pharm, Wingate, NC 28174 USA
关键词
Skeletal muscle; Cell death; Mitochondria; Oxidative stress; Atrophy; GROWTH-FACTOR-I; SKELETAL-MUSCLE ATROPHY; DEXAMETHASONE-INDUCED APOPTOSIS; STEROID-INDUCED MYOPATHY; SATURATED FATTY-ACIDS; THYMOCYTE APOPTOSIS; PROTEIN-SYNTHESIS; INSULIN-RESISTANCE; TREATED RATS; MITOCHONDRIAL DYSFUNCTION;
D O I
10.1016/j.jsbmb.2009.05.014
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Glucocorticoid-induced myopathy is a common side effect of chronic glucocorticoid therapy. Several mechanisms are currently being examined as ways in which glucocorticoid-induced myopathy occurs. These include apoptotic signaling through mitochondrial-mediated and Fas-mediated apoptosis, the role of the proteosome, the suppression of the IGF-1 signaling, and the role of ceramide in glucocorticoid-induced apoptosis and myopathy. It is difficult to differentiate which mechanism may be the initiating event responsible for the induction of apoptosis; however, all of the mechanisms play a vital role in glucocorticoid-induced myopathy. (c) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1 / 7
页数:7
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