Towards the total synthesis of Calyculin C: preparation of the C13-C25 spirocyclic core

被引：10

作者：

Habrant, Damien ^{[1
]}

Stewart, Alan J. W. ^{[1
]}

Koskinen, Ari M. P. ^{[1
]}

机构：

[1] Helsinki Univ Technol, Organ Chem Lab, FIN-02015 Espoo, Finland

来源：

TETRAHEDRON | 2009年 / 65卷 / 38期

基金：

芬兰科学院;

关键词：

SPONGE DISCODERMIA-CALYX; PROTEIN PHOSPHATASE-1; ASYMMETRIC-SYNTHESIS; C-16-C-25; FRAGMENT; TERMINAL ALKYNES; SILYL ETHERS; ALDEHYDES; ACID; STEREOSELECTIVITY; (+)-CALYCULIN-A;

D O I：

10.1016/j.tet.2009.07.070

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereoselective synthesis of the C-13-C-25 Of Calyculin C is described. Key steps involve the coupling of a terminal acetylene with a thiol ester and subsequent spirocyclisation using a double intramolecular hetero-Michael addition. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：7927 / 7934

页数：8

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