Phototherapeutic Release of Nitric Oxide with Engineered Nanoconstructs

被引:29
作者
Fraix, Aurore [1 ]
Marino, Nino [1 ]
Sortino, Salvatore [1 ]
机构
[1] Univ Catania, Dept Drug Sci, Lab Photochem, I-95125 Catania, Italy
来源
LIGHT-RESPONSIVE NANOSTRUCTURED SYSTEMS FOR APPLICATIONS IN NANOMEDICINE | 2016年 / 370卷
关键词
Antibacterial therapy; Cancer therapy; Fluorescence imaging; Gel; Light; Nanomaterials; Nanoparticles; Nitric oxide; Polymers; FUNCTIONAL CORE/SHELL NANOPARTICLES; ASSEMBLED GOLD NANOPARTICLES; DUAL-COLOR FLUORESCENCE; SUPRAMOLECULAR HYDROGEL; POLYMER NANOPARTICLES; SILVER NANOPARTICLES; VISIBLE-LIGHT; QUANTUM DOTS; NO DELIVERY; CANCER;
D O I
10.1007/978-3-319-22942-3_8
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
The multiple role nitric oxide (NO) plays in a number of physiological and pathophysiological processes has, over the last few years, stimulated a massive interest in the development of new strategies and methods for generating NO in a controlled way, with the exciting prospect of tackling important diseases. Photochemical precursors of NO are particularly suited to this end because light triggering permits an exquisite control of location and timing of NO delivery. Integration of NO photodonors within the structure of appropriate materials represents a key step in the fabrication of functional devices for phototherapeutic applications. It also offers the advantage of concentrating a large number of chromophores in a restricted area with the result of significantly increasing the NO reservoir and the light harvesting properties. We present here an overview of the most significant advances made in the last 5 years in the fabrication of engineered nanoconstructs able to delivery NO under the exclusive control of light inputs, highlighting the logical design and their potential applications in battling cancer and bacterial infections.
引用
收藏
页码:225 / 257
页数:33
相关论文
共 116 条
[1]   β-Cyclodextrin polymer nanoparticles as carriers for doxorubicin and artemisinin: a spectroscopic and photophysical study [J].
Anand, Resmi ;
Manoli, Francesco ;
Manet, Ilse ;
Daoud-Mahammed, Samia ;
Agostoni, Valentina ;
Gref, Ruxandra ;
Monti, Sandra .
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 2012, 11 (08) :1285-1292
[2]  
[Anonymous], CANC MED
[3]  
[Anonymous], 2012, FUNDAMENTALS LIGHT M, DOI DOI 10.1002/9781118382905.CH7
[4]   High-relaxivity magnetic resonance imaging (MRI) contrast agent based on supramolecular assembly between a gadolinium chelate, a modified dextran, and poly-β-cyclodextrin [J].
Battistini, Elisa ;
Gianolio, Eliana ;
Gref, Ruxandra ;
Couvreur, Patrick ;
Fuzerova, Silvia ;
Othman, Mohammad ;
Aime, Silvio ;
Badet, Bernard ;
Durand, Philippe .
CHEMISTRY-A EUROPEAN JOURNAL, 2008, 14 (15) :4551-4561
[5]   Nitric Oxide Releasing Materials Triggered by Near-Infrared Excitation Through Tissue Filters [J].
Burks, Peter T. ;
Garcia, John V. ;
GonzalezIrias, Ricardo ;
Tillman, Jason T. ;
Niu, Mutong ;
Mikhailovsky, Alexander A. ;
Zhang, Jinping ;
Zhang, Fan ;
Ford, Peter C. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (48) :18145-18152
[6]   Quantum Dot Photoluminescence Quenching by Cr(III) Complexes. Photosensitized Reactions and Evidence for a FRET Mechanism [J].
Burks, Peter T. ;
Ostrowski, Alexis D. ;
Mikhailovsky, Alexander A. ;
Chan, Emory M. ;
Wagenknecht, Paul S. ;
Ford, Peter C. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 134 (32) :13266-13275
[7]   Highly photoresponsive monolayer-protected gold clusters by self- assembly of a cyclodextrin-azobenzene-derived supramolecular complex [J].
Callari, F ;
Petralia, S ;
Sortino, S .
CHEMICAL COMMUNICATIONS, 2006, (09) :1009-1011
[8]   Carbon dots for multiphoton bioimaging [J].
Cao, Li ;
Wang, Xin ;
Meziani, Mohammed J. ;
Lu, Fushen ;
Wang, Haifang ;
Luo, Pengju G. ;
Lin, Yi ;
Harruff, Barbara A. ;
Veca, L. Monica ;
Murray, Davoy ;
Xie, Su-Yuan ;
Sun, Ya-Ping .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (37) :11318-+
[9]   Nitric oxide release: Part II. Therapeutic applications [J].
Carpenter, Alexis W. ;
Schoenfisch, Mark H. .
CHEMICAL SOCIETY REVIEWS, 2012, 41 (10) :3742-3752
[10]   A multifunctional nanoassembly of mesogen-bearing amphiphiles and porphyrins for the simultaneous photodelivery of nitric oxide and singlet oxygen [J].
Caruso, Elisa B. ;
Cicciarella, Enzo ;
Sortino, Salvatore .
CHEMICAL COMMUNICATIONS, 2007, (47) :5028-5030