Studying the interactions of drugs and hydrophobic model membranes using contact angle goniometry

被引：4

作者：

Ikonen, Marjukka ^{[1
]}

Murtomaki, Lasse ^{[1
]}

Kontturi, Kyosti ^{[1
]}

机构：

[1] Helsinki Univ Technol, Phys Chem & Electrochem Lab, FI-02015 Helsinki, Finland

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2009年 / 71卷 / 01期

关键词：

Drug; Partition coefficient; Adsorption; Contact angle; Surface tension; SELF-ASSEMBLED MONOLAYERS; WATER PARTITION-COEFFICIENTS; PROPRANOLOL HYDROCHLORIDE; ELECTROLYTE CONCENTRATION; CACO-2; MONOLAYERS; SURFACE-ACTIVITY; IONIZABLE DRUGS; PERMEABILITY; ASSOCIATION; TEMPERATURE;

D O I：

10.1016/j.colsurfb.2009.01.013

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

This study demonstrates a method where contact angle goniometry combined with surface tension measurements is used to assess the interactions of drugs with the hydrophobic core of a biological membrane. To this end, self-assembled monolayers (SAMs) of two alkanethiol and one thiolipid on Au(111) surfaces are used as model membranes and their interaction with six beta-blockers is studied. The Gibbs equation and the Langmuir adsorption isotherm are used to determine the partition coefficients for the adsorption of the drugs, which are compared to the octanol-water partition coefficients as well as the liposome-water partition coefficients. The ability of the different SAMs to serve as model membranes in partitioning of drugs is discussed. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：107 / 112

页数：6