Activation of Immune Response in Disease Dynamics via Controlled Drug Scheduling

被引：18

作者：

Chang, Hyeygjeon ^{[1
]}

Astolfi, Alessandro ^{[1
,2
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Elect & Elect Engn, London, England

[2] Univ Roma Tor Vergata, Dipartimento Informat Sistemi & Prod, I-00133 Rome, Italy

来源：

IEEE TRANSACTIONS ON AUTOMATION SCIENCE AND ENGINEERING | 2009年 / 6卷 / 02期

关键词：

Biological systems; disease dynamics; human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) models; long-term nonprogressor; HIV-INFECTION; MULTIDRUG THERAPIES; HIV/AIDS; MODEL;

D O I：

10.1109/TASE.2008.2008156

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

The human immunodeficiency virus (HIV) infection, that causes acquired immune deficiency syndrome (AIDS), is a dynamic process that can be modeled via differential equations. The primary goal of this paper is to introduce a control philosophy to boost the response of the immune system by means of drug scheduling. The control purpose is to steer the system to an equilibrium condition known as long-term nonprogressor, which corresponds to an infected patient that does not develop the symptoms of AIDS. The feasibility of the control methodology is illustrated via simulations on two HIV dynamic models and on a general disease model.

引用

页码：248 / 255

页数：8

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