Pathogen recognition in the innate immune response

被引：434

作者：

Kumar, Himanshu ^{[1
,2
]}

Kawai, Taro ^{[1
,2
]}

Akira, Shizuo ^{[1
,2
]}

机构：

[1] Osaka Univ, Host Def Lab, WPI Immunol Frontier Res Ctr, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Dept Host Def, Microbial Dis Res Inst, Suita, Osaka 5650871, Japan

来源：

BIOCHEMICAL JOURNAL | 2009年 / 420卷

基金：

日本学术振兴会;

关键词：

innate immune response; Nod-like receptor (NLR); pathogen recognition; retinoic acid-inducible gene-I receptor (RIG-I-like receptor; RLR); Toll-like receptor (TLR); TOLL-LIKE-RECEPTORS; NF-KAPPA-B; PLASMACYTOID DENDRITIC CELLS; DOUBLE-STRANDED-RNA; AIRWAY EPITHELIAL-CELLS; RESPIRATORY-SYNCYTIAL-VIRUS; MYD88-DEPENDENT SIGNALING PATHWAY; PSEUDOMONAS-AERUGINOSA FLAGELLIN; INDEPENDENT ANTIVIRAL RESPONSE; PYOGENIC BACTERIAL-INFECTIONS;

D O I：

10.1042/BJ20090272

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Immunity against microbial pathogens primarily depends on the recognition of pathogen components by innate receptors expressed on immune and non-immune cells. Innate receptors are evolutionarily conserved germ-line-encoded proteins and include TLRs (Toll-like receptors), RLRs [RIG-I (retinoic acid-inducible gene-I)-like receptors] and NLRs (Nod-like receptors). These receptors recognize pathogens or pathogen-derived products in different cellular compartments, such as the plasma membrane, the endosomes or the cytoplasm, and induce the expression of cytokines, chemokines and co-stimulatory molecules to eliminate pathogens and instruct pathogen-specific adaptive immune responses. In the present review, we will discuss the recent progress in the study of pathogen recognition by TLRs, RLRs and NLRs and their signalling pathways.

引用

页码：1 / 16

页数：16

共 211 条

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