Multiple potential targets of opioids in the treatment of acute respiratory distress syndrome from COVID-19

被引：6

作者：

Cismaru, Cosmin Andrei ^{[1
,2
]}

Cismaru, Gabriel Laurentiu ^{[3
]}

Nabavi, Seyed Fazel ^{[4
]}

Ghanei, Mostafa ^{[5
]}

Burz, Claudia Cristina ^{[2
]}

Nabavi, Seyed Mohammad ^{[4
]}

Berindan Neagoe, Ioana ^{[1
,6
]}

机构：

[1] Iuliu Hatieganu Univ Med & Pharm, Res Ctr Funct Genom Biomed & Translat Med, Str Gh Marinescu 23, Cluj Napoca 400337, Romania

[2] Iuliu Hatieganu Univ Med & Pharm, Dept Funct Sci Immunol & Allergol, Cluj Napoca, Romania

[3] Iuliu Hatieganu Univ Med & Pharm, Dept Internal Med Cardiol Rehabilitat, Cluj Napoca, Romania

[4] Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, Tehran, Iran

[5] Baqiyatallah Univ Med Sci, Syst Biol & Poisoning Inst, Chem Injuries Res Ctr, Tehran, Iran

[6] Oncol Inst Prof Dr Ion Chiricuta, Funct Genom Dept, Cluj Napoca, Romania

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2021年 / 25卷 / 01期

关键词：

ARDS; COVID-19; cytokine storm; dyspnoea; immunomodulation; opioids; PALLIATIVE CARE PATIENTS; VENTILATORY RESPONSE; SYMPTOMATIC THERAPY; CANCER-PATIENTS; DYSPNEA; MORPHINE; RECEPTORS; PAIN; RECOMMENDATIONS; BREATHLESSNESS;

D O I：

10.1111/jcmm.15927

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

COVID-19 can present with a variety of clinical features, ranging from asymptomatic or mild respiratory symptoms to fulminant acute respiratory distress syndrome (ARDS) depending on the host's immune responses and the extent of the associated pathologies. This implies that several measures need to be taken to limit severely impairing symptoms caused by viral-induced pathology in vital organs. Opioids are most exploited for their analgesic effects but their usage in the palliation of dyspnoea, immunomodulation and lysosomotropism may represent potential usages of opioids in COVID-19. Here, we describe the mechanisms involved in each of these potential usages, highlighting the benefits of using opioids in the treatment of ARDS from SARS-CoV-2 infection.

引用

页码：591 / 595

页数：5

共 62 条

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