Biochemical functionality of magnetic particles as nanosensors: how far away are we to implement them into clinical practice?

被引：20
作者：
Doswald, Simon [1 ]
Stark, Wendelin Jan [1 ]
Beck-Schimmer, Beatrice [2 ,3 ]
机构：
[1] Swiss Fed Inst Technol, Inst Chem & Bioengn, Zurich, Switzerland
[2] Univ Zurich, Inst Anesthesiol, Raemistr 100, CH-8091 Zurich, Switzerland
[3] Univ Hosp Zurich, Raemistr 100, CH-8091 Zurich, Switzerland
来源：
JOURNAL OF NANOBIOTECHNOLOGY | 2019年 / 17卷 / 1期
关键词：
Magnetic nanoparticle; Nanosensors; Medical applications; Blood purification; Risk assessment; IRON-OXIDE NANOPARTICLES; CIRCULATING TUMOR-CELLS; LONG-TERM EXPOSURE; IN-VIVO; DRUG-DELIVERY; HYPERBRANCHED POLYGLYCEROLS; INORGANIC NANOPARTICLES; SILVER NANOPARTICLES; METAL NANOPARTICLES; CANCER;
D O I：
10.1186/s12951-019-0506-y
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Magnetic nanosensors have become attractive instruments for the diagnosis and treatment of different diseases. They represent an efficient carrier system in drug delivery or in transporting contrast agents. For such purposes, magnetic nanosensors are used in vivo (intracorporeal application). To remove specific compounds from blood, magnetic nanosensors act as elimination system, which represents an extracorporeal approach. This review discusses principles, advantages and risks on recent advances in the field of magnetic nanosensors. First, synthesis methods for magnetic nanosensors and possibilities for enhancement of biocompatibility with different coating materials are addressed. Then, attention is devoted to clinical applications, in which nanosensors are or may be used as carrier- and elimination systems in the near future. Finally, risk considerations and possible effects of nanomaterials are discussed when working towards clinical applications with magnetic nanosensors.
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页数：11
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