Granulomatous Interstitial Nephritis as a Manifestation of Crohn Disease

被引：17

作者：

Colvin, Robert B. ^{[1
]}

Traum, Avram Z. ^{[2
]}

Taheri, Diana ^{[1
,3
,4
]}

Jafari, Mohsen ^{[4
]}

Dolatkhah, Shahaboddin ^{[5
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Pathol, Boston, MA USA

[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Nephrol, Boston, MA USA

[3] Isfahan Kidney Dis Res Ctr, Esfahan, Iran

[4] Isfahan Univ Med Sci, Sch Med, Dept Pathol, Esfahan 8168788131, Iran

[5] Isfahan Univ Med Sci, Fac Med, Esfahan 8168788131, Iran

来源：

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE | 2014年 / 138卷 / 01期

关键词：

INFLAMMATORY-BOWEL-DISEASE; TUBULOINTERSTITIAL NEPHRITIS; 5-AMINOSALICYLIC ACID; RENAL-FUNCTION; MESALAZINE; ADOLESCENT;

D O I：

10.5858/arpa.2012-0224-CR

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Granulomatous interstitial nephritis is a rare extraintestinal manifestation of Crohn disease that has been described previously in 4 patients. We report a 23-year-old man with a history of Crohn disease since age 6 years who was admitted to the hospital for weight loss, fever, and bloody diarrhea in the midst of a recent flare up during the past 2 months. Investigations revealed anemia, high erythrocyte sedimentation rate, high C-reactive protein level, and an elevated serum creatinine level. Histopathologic examination of tissue specimens obtained at renal biopsy demonstrated granulomatous interstitial nephritis. Crohn disease needs to be in the differential diagnosis of granulomatous interstitial nephritis and can be a manifestation of drug allergy or the Crohn disease itself.

引用

页码：125 / 127

页数：3

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