Estrogen receptor-α mRNA variants in murine and human tissues

被引：16
|
作者：
Lu, B
Dotzlaw, H
Leygue, E
Murphy, LJ
Watson, PH
Murphy, LC
机构：
[1] Univ Manitoba, Dept Biochem & Mol Biol, Winnipeg, MB R3E 0W3, Canada
[2] Univ Manitoba, Dept Physiol, Winnipeg, MB R3E 0W3, Canada
[3] Univ Manitoba, Dept Pathol, Winnipeg, MB R3E 0W3, Canada
来源：
MOLECULAR AND CELLULAR ENDOCRINOLOGY | 1999年 / 158卷 / 1-2期
基金：
英国医学研究理事会;
关键词：
alternative splicing; estrogen receptor-alpha; species differences; variant mRNAs;
D O I：
10.1016/S0303-7207(99)00169-0
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A side-by-side comparison of several normal mouse and human tissues was undertaken in order to determine if exon-deleted variant ER-alpha mRNAs are expressed in the mouse. The data showed that the complex pattern of ER-alpha alternative splicing that is detected in multiple human tissues was not apparent in murine tissues. Only low levels of an exon-4 deleted ER-alpha transcript were detected in murine tissues, although multiple relatively abundant exon-deleted ER-alpha transcripts were detected in human tissues. The data support a species-specific difference in the expression of ER-alpha variant mRNAs between mouse and human. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：153 / 161
页数：9
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