Hepatoprotective effects of Lycium chinense Miller fruit and its constituent betaine in CCl4-induced hepatic damage in rats

被引：68

作者：

Ahn, Meejung ^{[1
]}

Park, Jong Sang ^{[2
]}

Chae, Sungwook ^{[3
]}

Kim, Seungjoon ^{[4
]}

Moon, Changjong ^{[5
]}

Hyun, Jin Won ^{[6
,7
]}

Shin, Taekyun ^{[8
,9
]}

机构：

[1] Jeju Natl Univ, Sch Med, Cheju 690756, South Korea

[2] HLSGLOBAL Inc, Taejon 302220, South Korea

[3] Korea Inst Oriental Med, Aging Res Lab, Taejon 305811, South Korea

[4] Kyungpook Natl Univ, Coll Vet Med, Taegu 702701, South Korea

[5] Chonnam Natl Univ, Dept Vet Anat, Coll Vet Med, Kwangju 500757, South Korea

[6] Jeju Natl Univ, Sch Med, Cheju 690756, South Korea

[7] Jeju Natl Univ, Inst Nucl Sci & Technol, Cheju 690756, South Korea

[8] Jeju Natl Univ, Coll Vet Med, Cheju 690756, South Korea

[9] Jeju Natl Univ, Vet Med Res Inst, Cheju 690756, South Korea

来源：

ACTA HISTOCHEMICA | 2014年 / 116卷 / 06期

关键词：

Carbon tetrachloride; Lycium chinense Miller; Betaine; Hepatotoxicity; Rat; ACUTE LIVER-INJURY; INDUCED HEPATOTOXICITY; CELLS; HEPATOCYTES; ALLEVIATION; METABOLISM; COUMARIN; RADICALS; FIBROSIS; MODEL;

D O I：

10.1016/j.acthis.2014.05.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The hepatoprotective activities of Lycium chinense Miller (LC) fruit extract and its component betaine were investigated under carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. The treatment of LC fruit extract significantly suppressed the increase of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the sera of CCl4 injured rats, and restored the decreased levels of anti-oxidant enzymes such as total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and suppressed the expression of inflammatory mediators including inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-1 and -2. To visualize the potential activity of betaine, a component of LC fruit, betaine was substituted for LC extract in CCl4 injured rats. The biochemical profile in CCl4 injured rats co-treated with betaine matched those of LC fruit treated CCl4 injured rats. The ameliorative effects of LC extract, as well as betaine, were also confirmed by histopathological examination. Collectively, the present findings imply that LC fruit, via its component betaine, mitigate CCl4-induced hepatic injury by increasing antioxidative activity and decreasing inflammatory mediators including iNOS and COX-1/COX-2. (C) 2014 Elsevier GmbH. All rights reserved.

引用

页码：1104 / 1112

页数：9

共 26 条

[1] Betaine lowers elevated S-adenosylhomocysteine levels in hepatocytes from ethanol-fed rats [J].