Metal-free oxidative direct C(sp3)-H bond functionalization of ethers with α,α-diaryl allylic alcohols

被引：109
|
作者：
Chu, Xue-Qiang
Meng, Hua
Zi, You
Xu, Xiao-Ping [1 ]
Ji, Shun-Jun
机构：
[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 68期
基金：
中国国家自然科学基金;
关键词：
SP(3) C-H; CARBON-HYDROGEN BONDS; ISOCYANIDE INSERTION; CATALYZED TRIFLUOROMETHYLATION; ANTAGONIST LY426965; EFFICIENT SYNTHESIS; 1,2-ARYL MIGRATION; AEROBIC CONDITIONS; ACTIVATED ALKENES; BENZOYL PEROXIDE;
D O I：
10.1039/c4cc04282d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A metal-free method for direct C(sp(3))-H bond functionalization of simple ethers with alpha,alpha-diaryl allylic alcohols is described. The established protocol provides facile access to alpha-aryl-beta-oxyalkylated carbonyl ketones via radical addition and a 1,2-aryl migration cascade process. An application of the product has been demonstrated in the synthesis of a serotonin antagonist.
引用
收藏
页码：9718 / 9721
页数：4
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