Dexras1 is a small GTPase and plays a central role in neuronal iron trafficking. We have shown that stimulation of glutamate receptors activates neuronal nitric oxide synthase, leading to S-nitrosylation of Dexras1 and a physiological increase in iron uptake. Here we report that Dexras1 is phosphorylated by protein kinase A (PICA) on serine 253, leading to a suppression of iron influx. These effects were directly associated with the levels of S-nitrosylated Dexras1, whereby PICA activation reduced Dexras1 S-nitrosylation in a dose dependent manner. Moreover, we found that adiponectin modulates Dexras1 via PICA. Hence these findings suggest the involvement of the PICA pathway in modulating glutamate-mediated ROS in neurons, and hint to a functional crosstalk between S-nitrosylation and phosphorylation. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
机构:Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Programa Neurobiol, UFRJ,Ctr Ciencias Saude, BR-21949900 Rio De Janeiro, Brazil
Adao-Novaes, Juliana
Belem Guterres, Ceulem de Cassia
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机构:Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Programa Neurobiol, UFRJ,Ctr Ciencias Saude, BR-21949900 Rio De Janeiro, Brazil
Belem Guterres, Ceulem de Cassia
Ledo Santos da Silva, Ana Gabriela
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机构:Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Programa Neurobiol, UFRJ,Ctr Ciencias Saude, BR-21949900 Rio De Janeiro, Brazil
Ledo Santos da Silva, Ana Gabriela
Campello-Costa, Paula
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Univ Fed Fluminense, Ctr Estudos Gerais, Inst Biol, Programa Neuroimunol, Niteroi, RJ, BrazilUniv Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Programa Neurobiol, UFRJ,Ctr Ciencias Saude, BR-21949900 Rio De Janeiro, Brazil
Campello-Costa, Paula
Linden, Rafael
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机构:Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Programa Neurobiol, UFRJ,Ctr Ciencias Saude, BR-21949900 Rio De Janeiro, Brazil
Linden, Rafael
Sholl-Franco, Alfred
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Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Programa Neurobiol, UFRJ,Ctr Ciencias Saude, BR-21949900 Rio De Janeiro, BrazilUniv Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Programa Neurobiol, UFRJ,Ctr Ciencias Saude, BR-21949900 Rio De Janeiro, Brazil
机构:Louisiana State Univ, Ctr Hlth Sci, Dept Pharmacol & Expt Therapeut, New Orleans, LA 70112 USA
Blumer, JB
Cismowski, MJ
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h-index: 0
机构:Louisiana State Univ, Ctr Hlth Sci, Dept Pharmacol & Expt Therapeut, New Orleans, LA 70112 USA
Cismowski, MJ
Sato, M
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机构:Louisiana State Univ, Ctr Hlth Sci, Dept Pharmacol & Expt Therapeut, New Orleans, LA 70112 USA
Sato, M
Lanier, SM
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Louisiana State Univ, Ctr Hlth Sci, Dept Pharmacol & Expt Therapeut, New Orleans, LA 70112 USALouisiana State Univ, Ctr Hlth Sci, Dept Pharmacol & Expt Therapeut, New Orleans, LA 70112 USA
机构:
Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
Du, Fang
Qian, Zhong-ming
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Fudan Univ, Sch Pharm, Neuropharmacol Lab, Shanghai 201203, Peoples R ChinaChinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
Qian, Zhong-ming
Gong, Qi
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Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
Fudan Univ, Sch Pharm, Neuropharmacol Lab, Shanghai 201203, Peoples R ChinaChinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
Gong, Qi
Zhu, Zhou Jin
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Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
Zhu, Zhou Jin
Lu, Lina
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Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
Fudan Univ, Sch Pharm, Neuropharmacol Lab, Shanghai 201203, Peoples R ChinaChinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
Lu, Lina
Ke, Ya
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Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
Fudan Univ, Sch Pharm, Neuropharmacol Lab, Shanghai 201203, Peoples R ChinaChinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
机构:Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Programa Neurobiol, UFRJ,Ctr Ciencias Saude, BR-21949900 Rio De Janeiro, Brazil
Adao-Novaes, Juliana
Belem Guterres, Ceulem de Cassia
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机构:Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Programa Neurobiol, UFRJ,Ctr Ciencias Saude, BR-21949900 Rio De Janeiro, Brazil
Belem Guterres, Ceulem de Cassia
Ledo Santos da Silva, Ana Gabriela
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h-index: 0
机构:Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Programa Neurobiol, UFRJ,Ctr Ciencias Saude, BR-21949900 Rio De Janeiro, Brazil
Ledo Santos da Silva, Ana Gabriela
Campello-Costa, Paula
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Fluminense, Ctr Estudos Gerais, Inst Biol, Programa Neuroimunol, Niteroi, RJ, BrazilUniv Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Programa Neurobiol, UFRJ,Ctr Ciencias Saude, BR-21949900 Rio De Janeiro, Brazil
Campello-Costa, Paula
Linden, Rafael
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h-index: 0
机构:Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Programa Neurobiol, UFRJ,Ctr Ciencias Saude, BR-21949900 Rio De Janeiro, Brazil
Linden, Rafael
Sholl-Franco, Alfred
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Programa Neurobiol, UFRJ,Ctr Ciencias Saude, BR-21949900 Rio De Janeiro, BrazilUniv Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Programa Neurobiol, UFRJ,Ctr Ciencias Saude, BR-21949900 Rio De Janeiro, Brazil
机构:Louisiana State Univ, Ctr Hlth Sci, Dept Pharmacol & Expt Therapeut, New Orleans, LA 70112 USA
Blumer, JB
Cismowski, MJ
论文数: 0引用数: 0
h-index: 0
机构:Louisiana State Univ, Ctr Hlth Sci, Dept Pharmacol & Expt Therapeut, New Orleans, LA 70112 USA
Cismowski, MJ
Sato, M
论文数: 0引用数: 0
h-index: 0
机构:Louisiana State Univ, Ctr Hlth Sci, Dept Pharmacol & Expt Therapeut, New Orleans, LA 70112 USA
Sato, M
Lanier, SM
论文数: 0引用数: 0
h-index: 0
机构:
Louisiana State Univ, Ctr Hlth Sci, Dept Pharmacol & Expt Therapeut, New Orleans, LA 70112 USALouisiana State Univ, Ctr Hlth Sci, Dept Pharmacol & Expt Therapeut, New Orleans, LA 70112 USA
机构:
Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
Du, Fang
Qian, Zhong-ming
论文数: 0引用数: 0
h-index: 0
机构:
Fudan Univ, Sch Pharm, Neuropharmacol Lab, Shanghai 201203, Peoples R ChinaChinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
Qian, Zhong-ming
Gong, Qi
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
Fudan Univ, Sch Pharm, Neuropharmacol Lab, Shanghai 201203, Peoples R ChinaChinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
Gong, Qi
Zhu, Zhou Jin
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h-index: 0
机构:
Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
Zhu, Zhou Jin
Lu, Lina
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
Fudan Univ, Sch Pharm, Neuropharmacol Lab, Shanghai 201203, Peoples R ChinaChinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
Lu, Lina
Ke, Ya
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
Fudan Univ, Sch Pharm, Neuropharmacol Lab, Shanghai 201203, Peoples R ChinaChinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China