Clear Cell Sarcoma of the Kidney in a Child with Fanconi Anemia

被引：5

作者：

Bittar, Humberto E. Trejo ^{[1
]}

Radder, Josiah E. ^{[2
]}

Ranganathan, Sarangarajan ^{[1
]}

Srinivasan, Abhay ^{[3
]}

Madan-Khetarpal, Suneeta ^{[4
]}

Reyes-Mugica, Miguel ^{[1
]}

机构：

[1] Univ Pittsburgh, Childrens Hosp Pittsburgh, Med Ctr, Div Pediat Pathol, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Sch Med, Div Pulm Allergy & Crit Care Med, Pittsburgh, PA USA

[3] Univ Pittsburgh, Childrens Hosp Pittsburgh, Med Ctr, Div Pediat Radiol, Pittsburgh, PA 15213 USA

[4] Univ Pittsburgh, Childrens Hosp Pittsburgh, Med Ctr, Div Med Genet, Pittsburgh, PA 15213 USA

来源：

PEDIATRIC AND DEVELOPMENTAL PATHOLOGY | 2014年 / 17卷 / 04期

关键词：

Clear Cell Sarcoma of Kidney; CCSK; Fanconi anemia; cancer predisposition; pediatric renal cancer; RENAL TUMOR; CANCER; BRCA2; PERSPECTIVE; CARCINOMA; MUTATIONS;

D O I：

10.2350/14-03-1450-CR.1

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Patients with Fanconi anemia subgroup D1, attributable to biallelic mutations in BRCA2, have an increased risk of solid tumors. Tumors in the kidneys of these patients are almost exclusively Wilms tumor. We report the first recorded case, to our knowledge, of a Clear Cell Sarcoma of the Kidney in a patient with this cancer predisposition syndrome. We review different aspects of the need for careful clinical observation in patients of this complementation group, given their risk for malignancy.

引用

页码：297 / 301

页数：5

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