Tolerogenic dendritic cells

被引：151

作者：

Takenaka, Maisa C. ^{[1
]}

Quintana, Francisco J. ^{[1
,2
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Ann Romney Ctr Neurol Dis, 77 Ave Louis, Boston, MA 02115 USA

[2] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

来源：

SEMINARS IN IMMUNOPATHOLOGY | 2017年 / 39卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Dendritic cell; Tolerance; Autoimmunity; Nanoparticles; AhR; ARYL-HYDROCARBON RECEPTOR; REGULATORY T-CELLS; NF-KAPPA-B; MOUSE BONE-MARROW; RETINOIC ACID; AH RECEPTOR; IN-VIVO; GENE-EXPRESSION; SELF-TOLERANCE; STEADY-STATE;

D O I：

10.1007/s00281-016-0587-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Deficits in immunological tolerance against self-antigens and antigens provided by the diet and commensal microbiota can result in the development of inflammatory and autoimmune disorders. Dendritic cells (DCs) are pivotal regulators of the immune response, specialized in antigen presentation to drive T cell priming and differentiation. DCs also have a tolerogenic function, participating in the enforcement of central and peripheral tolerance and the resolution of ongoing immune responses. Thus, DCs control effector and regulatory mechanisms relevant to the pathology of autoimmune disorders. In this review, we discuss recent findings regarding the control of the adaptive immune response by tolerogenic DCs. A thorough understanding of the mechanisms that control the tolerogenic DC phenotype will guide the development of novel strategies for the treatment of autoimmunity.

引用

页码：113 / 120

页数：8

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