Infantile/Congenital High-Grade Gliomas: Molecular Features and Therapeutic Perspectives

被引：19

作者：

Ceglie, Giulia ^{[1
]}

Vinci, Maria ^{[1
]}

Carai, Andrea ^{[2
]}

Rossi, Sabrina ^{[3
]}

Colafati, Giovanna Stefania ^{[4
]}

Cacchione, Antonella ^{[1
]}

Tornesello, Assunta ^{[5
]}

Miele, Evelina ^{[1
]}

Locatelli, Franco ^{[1
,6
]}

Mastronuzzi, Angela ^{[1
]}

机构：

[1] Bambino Gesu Childrens Hosp IRCCS, Dept Oncohematol & Cell & Gene Therapy, Piazza St Onofrio 4, I-00146 Rome, Italy

[2] Bambino Gesu Childrens Hosp IRCCS, Dept Neurol & Psychiat Sci, Neurosurg Unit, Piazza St Onofrio 4, I-00146 Rome, Italy

[3] Bambino Gesu Childrens Hosp IRCCS, Dept Labs, Pathol Unit, Piazza St Onofrio 4, I-00146 Rome, Italy

[4] Bambino Gesu Childrens Hosp IRCCS, Dept Imaging, Neuroradiol Unit, Piazza St Onofrio 4, I-00146 Rome, Italy

[5] Osped Vito Fazzi, Pediat Oncol Unit, Piazza Filippo Muratore 1, I-73100 Lecce, Italy

[6] Univ Roma La Sapienza, Dept Maternal Infantile & Urol Sci, Piazzale Aldo Moro 5, I-00185 Rome, Italy

来源：

DIAGNOSTICS | 2020年 / 10卷 / 09期

关键词：

brain tumors; high-grade gliomas; congenital cancer; neuro-oncology; neonatal cancer; neurotrophic tyrosine receptor kinase; CONGENITAL GLIOBLASTOMA-MULTIFORME; CENTRAL-NERVOUS-SYSTEM; PEDIATRIC HIGH-GRADE; BRAIN-TUMORS; GENOMIC LANDSCAPE; INFANTS; FUSION; KINASE;

D O I：

10.3390/diagnostics10090648

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Brain tumors in infants account for less than 10% of all pediatric nervous system tumors. They include tumors diagnosed in fetal age, neonatal age and in the first years of life. Among these, high-grade gliomas (HGGs) are a specific entity with a paradoxical clinical course that sets them apart from their pediatric and adult counterparts. Currently, surgery represents the main therapeutic strategy in the management of these tumors. Chemotherapy does not have a well-defined role whilst radiotherapy is rarely performed, considering its late effects. Information about molecular characterization is still limited, but it could represent a new fundamental tool in the therapeutic perspective of these tumors. Chimeric proteins derived from the fusion of several genes with neurotrophic tyrosine receptor kinase mutations have been described in high-grade gliomas in infants as well as in neonatal age and the recent discovery of targeted drugs may change the long-term prognosis of these tumors, along with other target-driven therapies. The aim of this mini review is to highlight the recent advances in the diagnosis and treatment of high-grade gliomas in infants with a particular focus on the molecular landscape of these neoplasms and future clinical applications.

引用

页数：11

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