Breast Cancer Stem Cells: Eradication by Differentiation Therapy?

被引：40
作者：
Beug, Hartmut [1 ]
机构：
[1] Inst Mol Pathol, A-1030 Vienna, Austria
来源：
CELL | 2009年 / 138卷 / 04期
关键词：
EPITHELIAL-MESENCHYMAL TRANSITION;
D O I：
10.1016/j.cell.2009.08.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
During metastasis, migrating breast cancer stem cells undergo a loss of polarity leading to an epithelial-to-mesenchymal transition (EMT). Gupta et al. (2009) use this attribute of cancer stem cells to develop a high-throughput screen, which successfully identifies small molecules that specifically inhibit cancer stem cell proliferation through the induction of differentiation.
引用
收藏
页码：623 / 625
页数：4
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