Breast Cancer Stem Cells: Eradication by Differentiation Therapy?

被引：41

作者：

Beug, Hartmut ^{[1
]}

机构：

[1] Inst Mol Pathol, A-1030 Vienna, Austria

来源：

CELL | 2009年 / 138卷 / 04期

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION;

D O I：

10.1016/j.cell.2009.08.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During metastasis, migrating breast cancer stem cells undergo a loss of polarity leading to an epithelial-to-mesenchymal transition (EMT). Gupta et al. (2009) use this attribute of cancer stem cells to develop a high-throughput screen, which successfully identifies small molecules that specifically inhibit cancer stem cell proliferation through the induction of differentiation.

引用

收藏

页码：623 / 625

页数：4

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