Internal capsule size in good-outcome and poor-outcome schizophrenia

被引:24
作者
Brickman, Adam M.
Buchsbaum, Monte S.
Ivanov, Zlatin
Borod, Joan C.
Foldi, Nancy S.
Hahn, Eunice
Mitelman, Serge A.
Hazlett, Erin A.
Lincoln, Samantha J.
Newmark, Randall E.
Shihabuddin, Lina
机构
[1] Columbia Univ, Med Ctr, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10032 USA
[2] Mt Sinai Sch Med, Dept Psychiat, Neurosci PET Lab, New York, NY USA
[3] Queens Coll, Dept Psychol, Flushing, NY USA
[4] CUNY, Grad Ctr, New York, NY USA
[5] Mt Sinai Sch Med, Dept Neurol, New York, NY USA
[6] Winthrop Univ Hosp, Stony Brook Sch Med, Dept Med, Div Geriatr, Stony Brook, NY USA
关键词
D O I
10.1176/appi.neuropsych.18.3.364
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Converging lines of research suggest that white matter abnormalities may be central to the pathophysiology of schizophrenia. The purpose of this study was to examine regional white matter in the anterior limb of the internal capsules in patients with schizophrenia. The authors obtained high-resolution magnetic resonance imaging in 106 patients with schizophrenia and 42 age and sex-matched healthy comparison subjects. The area of the anterior limb of the internal capsule was measured at five proportionately spaced dorsal-to-ventral levels. Schizophrenia patients were divided into good-outcome and poor-outcome groups, based on longitudinal analysis of self-care deficits. Patients with poor-outcome had significantly smaller dorsal areas than healthy comparison subjects, but good-outcome patients did not differ from healthy comparison subjects. Larger relative volumes of the caudate, putamen, and thalamus tended to be associated with relatively larger volumes of the internal capsule in healthy comparison subjects and good-outcome patients, consistent with the known frontal-striatal-thalamic pathways. Larger ventricles were associated with smaller internal capsules, particularly in healthy comparison subjects. The findings suggest disruption of internal capsule fibers in poor-outcome patients with schizophrenia. These abnormalities may be independent of other structural changes in schizophrenia.
引用
收藏
页码:364 / 376
页数:13
相关论文
共 45 条
  • [1] ANDREASEN NC, 1992, ARCH GEN PSYCHIAT, V49, P615
  • [2] Morphological asymmetry in anterior limb of human internal capsule revealed by confocal laser and polarized light microscopy
    Axer, H
    Lippitz, BE
    von Keyserlingk, DG
    [J]. PSYCHIATRY RESEARCH-NEUROIMAGING, 1999, 91 (03) : 141 - 154
  • [3] Mapping of fiber orientation in human internal capsule by means of polarized light and confocal scanning laser microscopy
    Axer, H
    Von Keyserlingk, DG
    [J]. JOURNAL OF NEUROSCIENCE METHODS, 2000, 94 (02) : 165 - 175
  • [4] BREIER A, 1992, ARCH GEN PSYCHIAT, V49, P921
  • [5] Thalamus size and outcome in schizophrenia
    Brickman, AM
    Buchsbaum, MS
    Shihabuddin, L
    Byne, W
    Newmark, RE
    Brand, J
    Ahmed, S
    Mitelman, SA
    Hazlett, EA
    [J]. SCHIZOPHRENIA RESEARCH, 2004, 71 (2-3) : 473 - 484
  • [6] Structural evaluation of the prefrontal cortex in schizophrenia
    Buchanan, RW
    Vladar, K
    Barta, PE
    Pearlson, GD
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 1998, 155 (08) : 1049 - 1055
  • [7] MRI white matter diffusion anisotropy and PET metabolic rate in schizophrenia
    Buchsbaum, MS
    Tang, CY
    Peled, S
    Gudbjartsson, H
    Lu, DF
    Hazlett, EA
    Downhill, J
    Haznedar, M
    Fallon, JH
    Atlas, SW
    [J]. NEUROREPORT, 1998, 9 (03) : 425 - 430
  • [8] Caudate and putamen volumes in good and poor outcome patients with schizophrenia
    Buchsbaum, MS
    Shihabuddin, L
    Brickman, AM
    Miozzo, R
    Prikryl, R
    Shaw, R
    Davis, K
    [J]. SCHIZOPHRENIA RESEARCH, 2003, 64 (01) : 53 - 62
  • [9] Buchsbaum MS, 1996, AM J PSYCHIAT, V153, P191
  • [10] Magnetic resonance imaging of the thalamic mediodorsal nucleus and pulvinar in schizophrenia and schizotypal personality disorder
    Byne, W
    Buchsbaum, MS
    Kemether, E
    Hazlett, EA
    Shinwari, A
    Mitroupoulou, V
    Siever, LJ
    [J]. ARCHIVES OF GENERAL PSYCHIATRY, 2001, 58 (02) : 133 - 140