Distinct Features of Angioimmunoblastic T-Cell Lymphoma With Bone Marrow Involvement

被引:35
作者
Cho, Young-Uk [2 ]
Chi, Hyun-Sook [1 ]
Park, Chan-Jeoung
Jang, Seongsoo
Seo, Eul-Ju
Huh, Jooryung
机构
[1] Univ Ulsan, Dept Lab Med, Coll Med, Seoul 138736, South Korea
[2] Eulji Univ, Dept Lab Med, Sch Med, Eulji Gen Hosp, Seoul, South Korea
关键词
Angioimmunoblastic T-cell lymphoma; Bone marrow histomorphologic features; Immunophenotypic characteristics; EXPRESSION; BLOOD;
D O I
10.1309/AJCPQXKCHQH4VAJ5
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
We retrospectively reviewed the clinical and laboratory data and bone marrow (BM) histomorphologic features in 33 angioimmunoblastic T-cell lymphoma (AITL) cases. Paraffin-embedded BM core biopsy specimens were reacted immunohistochemically with antibodies to pan-T-cell markers, CD20, CD10, CD21, and bcl-6. The freguency of BM involvement was 70% (23/33). The following features were more significant in patients with than without BM involvement: fever, hepatosplenomegaly, pleural effusion, elevated lactate dehydrogenase level, hypoalbuminemia, hyponatremia, hypocalcemia, anemia, circulating atypical cells, hypercellular marrow, and plasmacytosis in the BM Morphologic features included nodular or interstitial infiltration in a paratrabecular distribution, periodic acid-Schiff-positive intercellular materials, mixed infiltrates of T and B cells, presence of clear cells, and blood vessel proliferation. Immunohistochemical assays revealed that CD5, bcl-6, and CD 10 were useful markers of BM infiltration. Seven cases with BM involvement were interpreted as negative,for lymphoma initially, mainly owing to insufficient information in nodal biopsy specimens. Several clinical and laboratory,features indicate BM involvement of AITL at diagnosis. Laboratory physicians should be more familiar with BM histomorphologic and immunophenotypic characteristics suggesting AITL infiltration to make accurate diagnoses even without prior nodal biopsies.
引用
收藏
页码:640 / 646
页数:7
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