Late onset mania as an organic syndrome: A review of case reports in the literature

Aims: Although First Episode Mania presenting over the age of 50 is reported in several cases, there has been little systematic compilation of these case reports. We report a review of case reports on these subjects. Methods: We undertook a literature search on MEDLINE, PsychInfo and EMBASE to identify case reports of First episode of mania or hypomania presenting over the age of 50. Results: 35 cases were identified. 29/35 (82%) had a suspected underlying organic cause. Organic causes included vascular causes, iatrogenic drug use, electrolyte imbalance, dementia and thyroid disease. Vascular risk factors were present in 17/35 cases (48%). in 10/35 (28%) of cases organic treatment contributed to successful remission of the manic episode. Limitations: As evidently not all cases have been reported the main limitation is that of publication bias for this paper. Any such hypothesis generated from studying these cases would require replication in prospective longitudinal trials of this cohort of patients. Conclusions: This review of case reports appears to add to evidence of late onset mania having an organic basis. Whether this is a separate organic syndrome remains to be established. Our provisional findings suggest that such patients should have a thorough medical and psychiatric screening in identifying an underlying cause. (c) 2015 Elsevier B.V. All rights reserved.