The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

被引：2855

作者：

Kopan, Raphael ^{[1
]}

Ilagan, Ma. Xenia G. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Dev Biol, St Louis, MO 63110 USA

来源：

CELL | 2009年 / 137卷 / 02期

基金：

美国国家卫生研究院;

关键词：

AMYLOID PRECURSOR PROTEIN; GAMMA-SECRETASE CLEAVAGE; LIGAND-BINDING DOMAIN; INHIBITS TUMOR-GROWTH; T-CELL DEVELOPMENT; NEURAL STEM-CELLS; C-ELEGANS; TRANSCRIPTION COMPLEXES; O-FUCOSE; IN-VIVO;

D O I：

10.1016/j.cell.2009.03.045

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Notch signaling regulates many aspects of metazoan development and tissue renewal. Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human disorders, from developmental syndromes to adult-onset diseases and cancer. Notch signaling is remarkably robust in most tissues even though each Notch molecule is irreversibly activated by proteolysis and signals only once without amplification by secondary messenger cascades. In this Review, we highlight recent studies in Notch signaling that reveal new molecular details about the regulation of ligand-mediated receptor activation, receptor proteolysis, and target selection.

引用

页码：216 / 233

页数：18

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