Metal-free α-alkylation of alcohols with para-quinone methides

被引：18

作者：

Qi, Jifeng ^{[1
]}

Deng, Ziyang ^{[1
]}

Huang, Bo ^{[1
]}

Cui, Sunliang ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Inst Drug Discovery & Design, Hangzhou 310058, Zhejiang, Peoples R China

[2] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2018年 / 16卷 / 15期

关键词：

CATALYTIC 1,6-CONJUGATE ADDITION/AROMATIZATION; CROSS-COUPLING REACTION; H BOND ACTIVATION; HETEROAROMATIC BASES; RADICAL PROCESS; SEC-ALCOHOLS; ACID; CARBON; FUNCTIONALIZATION; HYDROXYALKYLATION;

D O I：

10.1039/c8ob00568k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal-free alpha-alkylation of alcohols with para-quinone methides (p-QMs) for accessing alcohol-containing phenols and dihydroisocoumarins has been developed. The alcohols were converted to alpha-oxy radicals in the presence of di-tert-butyl peroxide (DTBP), which were added to p-QMs for aromatization and C(sp(3))-C(sp(3)) bond formation.

引用

页码：2762 / 2767

页数：6

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