Sphingosine-1-phosphate receptor-1 (S1P1) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease
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作者:
Karuppuchamy, T.
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机构:
Univ Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
VA San Diego Healthcare Syst, San Diego, CA 92161 USAUniv Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
Karuppuchamy, T.
[1
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Behrens, E-H
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Univ Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
VA San Diego Healthcare Syst, San Diego, CA 92161 USAUniv Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
Behrens, E-H
[1
,2
]
Gonzalez-Cabrera, P.
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机构:
Scripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USAUniv Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
Gonzalez-Cabrera, P.
[3
]
Sarkisyan, G.
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Scripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USAUniv Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
Sarkisyan, G.
[3
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Gima, L.
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机构:
Univ Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
VA San Diego Healthcare Syst, San Diego, CA 92161 USAUniv Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
Gima, L.
[1
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Boyer, J. D.
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机构:
Univ Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
VA San Diego Healthcare Syst, San Diego, CA 92161 USAUniv Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
Boyer, J. D.
[1
,2
]
Bamias, G.
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机构:
Laikon Gen Hosp, Acad Dept Gastroenterol, Athens, GreeceUniv Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
Bamias, G.
[4
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Jedlicka, P.
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机构:
Univ Colorado Hlth Sci, Dept Pathol, Aurora, CO USAUniv Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
Jedlicka, P.
[5
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Veny, M.
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Univ Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
VA San Diego Healthcare Syst, San Diego, CA 92161 USAUniv Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
Veny, M.
[1
,2
]
Clark, D.
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Univ Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
VA San Diego Healthcare Syst, San Diego, CA 92161 USAUniv Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
Clark, D.
[1
,2
]
Peach, R.
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机构:
Receptos Inc, La Jolla, CA USAUniv Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
Peach, R.
[6
]
Scott, F.
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Receptos Inc, La Jolla, CA USAUniv Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
Scott, F.
[6
]
Rosen, H.
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Scripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USAUniv Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
Rosen, H.
[3
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Rivera-Nieves, J.
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机构:
Univ Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
VA San Diego Healthcare Syst, San Diego, CA 92161 USAUniv Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
Rivera-Nieves, J.
[1
,2
]
机构:
[1] Univ Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
[2] VA San Diego Healthcare Syst, San Diego, CA 92161 USA
[3] Scripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USA
[4] Laikon Gen Hosp, Acad Dept Gastroenterol, Athens, Greece
[5] Univ Colorado Hlth Sci, Dept Pathol, Aurora, CO USA
The sphingosine-1-phosphate receptor-1 (S1P(1)) agonist ozanimod ameliorates ulcerative colitis, yet its mechanism of action is unknown. Here, we examine the cell subsets that express S1P(1) in intestine using S1P(1)-eGFP mice, the regulation of S1P(1) expression in lymphocytes after administration of dextran sulfate sodium (DSS), after colitis induced by transfer of CD4(+) CD45RB(hi) cells, and by crossing a mouse with TNF-driven ileitis with S1P(1)-eGFP mice. We then assayed the expression of enzymes that regulate intestinal S1P levels, and the effect of FTY720 on lymphocyte behavior and S1P(1) expression. We found that not only T and B cells express S1P(1), but also dendritic (DC) and endothelial cells. Furthermore, chronic but not acute inflammatory signals increased S1P(1) expression, while the enzymes that control tissue S1P levels in mice and humans with inflammatory bowel disease (IBD) were uniformly dysregulated, favoring synthesis over degradation. Finally, we observed that FTY720 reduced T-cell velocity and induced S1P(1) degradation and retention of Naive but not effector T cells. Our data demonstrate that chronic inflammation modulates S1P(1) expression and tissue S1P levels and suggests that the anti-inflammatory properties of S1PR agonists might not be solely due to their lymphopenic effects, but also due to potential effects on DC migration and vascular barrier function.
机构:
Cent South Univ, Xiangya Hosp 3, Ctr Expt Med, 138 Tongzipo Rd, Changsha 410013, Peoples R China
Cent South Univ, Xiangya Hosp 3, Dept Cardiol, Changsha, Peoples R ChinaCent South Univ, Xiangya Hosp 3, Ctr Expt Med, 138 Tongzipo Rd, Changsha 410013, Peoples R China
Wang, Xuewen
Chen, Shuhua
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机构:
Cent South Univ, Dept Biochem, Sch Life Sci, Changsha, Peoples R ChinaCent South Univ, Xiangya Hosp 3, Ctr Expt Med, 138 Tongzipo Rd, Changsha 410013, Peoples R China
Chen, Shuhua
Xiang, Hong
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机构:
Cent South Univ, Xiangya Hosp 3, Ctr Expt Med, 138 Tongzipo Rd, Changsha 410013, Peoples R ChinaCent South Univ, Xiangya Hosp 3, Ctr Expt Med, 138 Tongzipo Rd, Changsha 410013, Peoples R China
Xiang, Hong
Liang, Ziwei
论文数: 0引用数: 0
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机构:
Hunan Normal Univ, Yueyang Hosp, Dept Clin Lab, Yueyang, Peoples R ChinaCent South Univ, Xiangya Hosp 3, Ctr Expt Med, 138 Tongzipo Rd, Changsha 410013, Peoples R China
Liang, Ziwei
Lu, Hongwei
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Cent South Univ, Xiangya Hosp 3, Ctr Expt Med, 138 Tongzipo Rd, Changsha 410013, Peoples R China
Cent South Univ, Xiangya Hosp 3, Dept Cardiol, Changsha, Peoples R ChinaCent South Univ, Xiangya Hosp 3, Ctr Expt Med, 138 Tongzipo Rd, Changsha 410013, Peoples R China
机构:
Daiichi Sankyo Co Ltd, Cardiovascu Metab Res Labs, Shinagawa Ku, Tokyo 1408710, JapanDaiichi Sankyo Co Ltd, Cardiovascu Metab Res Labs, Shinagawa Ku, Tokyo 1408710, Japan
Yonesu, Kiyoaki
Nakamura, Tsuyoshi
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机构:
Daiichi Sankyo Co Ltd, Lead Discovery & Optimizat Res Labs 1, Shinagawa Ku, Tokyo 1408710, JapanDaiichi Sankyo Co Ltd, Cardiovascu Metab Res Labs, Shinagawa Ku, Tokyo 1408710, Japan
Nakamura, Tsuyoshi
Mizuno, Yumiko
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机构:
Daiichi Sankyo Co Ltd, Lead Discovery & Optimizat Res Labs 1, Shinagawa Ku, Tokyo 1408710, JapanDaiichi Sankyo Co Ltd, Cardiovascu Metab Res Labs, Shinagawa Ku, Tokyo 1408710, Japan
Mizuno, Yumiko
Suzuki, Chie
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机构:
Daiichi Sankyo Co Ltd, Lead Discovery & Optimizat Res Labs 1, Shinagawa Ku, Tokyo 1408710, JapanDaiichi Sankyo Co Ltd, Cardiovascu Metab Res Labs, Shinagawa Ku, Tokyo 1408710, Japan
Suzuki, Chie
Nagayama, Takahiro
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机构:
Daiichi Sankyo Co Ltd, Cardiovascu Metab Res Labs, Shinagawa Ku, Tokyo 1408710, JapanDaiichi Sankyo Co Ltd, Cardiovascu Metab Res Labs, Shinagawa Ku, Tokyo 1408710, Japan
Nagayama, Takahiro
Satoh, Susumu
论文数: 0引用数: 0
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机构:
Daiichi Sankyo RD Associe Co Ltd, Shinagawa Ku, Tokyo 1400001, JapanDaiichi Sankyo Co Ltd, Cardiovascu Metab Res Labs, Shinagawa Ku, Tokyo 1408710, Japan
Satoh, Susumu
Nara, Futoshi
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机构:
Daiichi Sankyo Co Ltd, Cardiovascu Metab Res Labs, Shinagawa Ku, Tokyo 1408710, JapanDaiichi Sankyo Co Ltd, Cardiovascu Metab Res Labs, Shinagawa Ku, Tokyo 1408710, Japan