Inhibitory and Enzyme-Kinetic Investigation of Chelerythrine and Lupeol Isolated from Zanthoxylum rhoifolium Against Krait Snake Venom Acetylcholinesterase

被引：5

作者：

Ahmad, Mustaq ^{[1
]}

Weber, Andreia D. ^{[2
]}

Zanon, Graciane ^{[2
]}

Tavares, Luciana de C. ^{[2
]}

Ilha, Vinicius ^{[2
]}

Dalcol, Ionara I. ^{[2
]}

Morel, Ademir F. ^{[2
]}

机构：

[1] Univ Sci & Technol, Dept Biotechnol, Bannu, Pakistan

[2] Univ Fed Santa Maria, Dept Quim, BR-97105900 Santa Maria, RS, Brazil

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2014年 / 25卷 / 01期

关键词：

Zanthoxylum rhoifolium; chelerythrine; lupeol; inhibition of AChE; venom of the Bungarus sindanus; STRUCTURAL MODIFICATION; IN-VITRO; BUNGARUS; CHOLINESTERASES; SANGUINARINE; RECEPTORS; BRAIN;

D O I：

10.5935/0103-5053.20130274

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The in vitro activity of chelerythrine and lupeol, two metabolites isolated from Zanthoxylum rhoifolium were studied against the venom of the snake Bungarus sindanus (Elapidae). The venom, which is highly toxic to humans, consists mainly by the enzyme acetylcholinesterase (AChE). Both compounds showed activity against the venom, and the alkaloid chelerythrine presented higher activity than did triterpene lupeol.

引用

页码：98 / 103

页数：6

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