CSPα in neurodegenerative diseases

被引：2
作者：
Huang, Liqin [1 ]
Zhang, Zhaohui [1 ]
机构：
[1] Wuhan Univ, Renmin Hosp, Dept Neurol, Wuhan, Peoples R China
来源：
FRONTIERS IN AGING NEUROSCIENCE | 2022年 / 14卷
关键词：
cysteine string proteins alpha; DNAJC5; adult-onset neuronal ceroid lipofuscinosis; neurodegenerative diseases; Alzheimer's disease; Parkinson's disease; CYSTEINE-STRING PROTEIN; NEURONAL CEROID-LIPOFUSCINOSIS; NEURAL STEM-CELLS; KUFS-DISEASE; DOMINANT FORM; CHAPERONE; ONSET; SECRETION; PALMITOYLATION; AGGREGATION;
D O I：
10.3389/fnagi.2022.1043384
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Adult-onset neuronal ceroid lipofuscinosis (ANCL) is a rare neurodegenerative disease characterized by epilepsy, cognitive degeneration, and motor disorders caused by mutations in the DNAJC5 gene. In addition to being associated with ANCL disease, the cysteine string proteins alpha (CSP alpha) encoded by the DNAJC5 gene have been implicated in several neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease. However, the pathogenic mechanism responsible for these neurodegenerative diseases has not yet been elucidated. Therefore, this study examines the functional properties of the CSP alpha protein and the related mechanisms of neurodegenerative diseases.
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页数：15
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