Regulation of macrophage development and function in peripheral tissues

被引：494
作者：
Lavin, Yonit
Mortha, Arthur
Rahman, Adeeb
Merad, Miriam [1 ]
机构：
[1] Icahn Sch Med Mt Sinai, Dept Oncol Sci, Tisch Canc Inst, New York, NY 10029 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2015年 / 15卷 / 12期
关键词：
TUMOR-ASSOCIATED MACROPHAGES; COLONY-STIMULATING FACTOR; SUBCAPSULAR SINUS MACROPHAGES; EPIDERMAL LANGERHANS CELLS; HEMATOPOIETIC STEM-CELLS; THROUGHPUT CHROMATIN IMMUNOPRECIPITATION; PULMONARY SURFACTANT HOMEOSTASIS; CONVENTIONAL DENDRITIC CELLS; ACTIVATED-RECEPTOR-GAMMA; SPLENIC MARGINAL ZONE;
D O I：
10.1038/nri3920
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Macrophages are immune cells of haematopoietic origin that provide crucial innate immune defence and have tissue-specific functions in the regulation and maintenance of organ homeostasis. Recent studies of macrophage ontogeny, as well as transcriptional and epigenetic identity, have started to reveal the decisive role of the tissue stroma in the regulation of macrophage function. These findings suggest that most macrophages seed the tissues during embryonic development and functionally specialize in response to cytokines and metabolites that are released by the stroma and drive the expression of unique transcription factors. In this Review, we discuss how recent insights into macrophage ontogeny and macrophage stroma interactions contribute to our understanding of the crosstalk that shapes macrophage function and the maintenance of organ integrity.
引用
收藏
页码：731 / 744
页数：14
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