Comparison of the structures of in vitro selected and natural binding sites of transcription factors

被引：0

作者：

Khlebodarova, T. M. ^{[1
]}

Podkolodnaya, O. A. ^{[1
]}

Ananko, E. A. ^{[1
]}

Ignatieva, E., V ^{[1
]}

机构：

[1] RAS, SB, Inst Cytol & Genet, Novosibirsk, Russia

来源：

Proceedings of the Fourth International Conference on Bioinformatics of Genome Regulation and Structure, Vol 1 | 2004年

关键词：

databases; transcription factor; binding sites; transcription regulation;

D O I：

暂无

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The information compiled in TRRD_ARTSITE database was used to compare the structures natural and in vitro selected binding sites for transcription factors USF1, SP1, YY1, RAR/RXR, and E2F/DP1. The structures of the natural and in vitro selected binding sites for each transcription factor analyzed were found similar, suggesting that at least for the factors in question the structures of binding sites correlated with the affinities of the corresponding factors. Insignificant differences in frequencies of certain nucleotides detected reflect the general trend, namely, a higher occurrence of moderate affinity sites in the natural population of sequences compared with the sequences obtained in vitro.

引用

收藏

页码：99 / 102

页数：4

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