Electronic Readout Enzyme-Linked Immunosorbent Assay with Organic Field-Effect Transistors as a Preeclampsia Prognostic

被引:39
作者
Hammock, Mallory L. [1 ]
Knopfmacher, Oren [1 ]
Ng, Tse Nga [2 ]
Tok, Jeffrey B. -H. [1 ]
Bao, Zhenan [1 ]
机构
[1] Stanford Univ, Dept Chem Engn, Stanford, CA 94305 USA
[2] Xerox Corp, Palo Alto Res Ctr, Palo Alto, CA 94304 USA
基金
美国国家科学基金会;
关键词
DEBYE-SCREENING LENGTH; PROTEIN-DETECTION; SOLUBLE ENDOGLIN; BIOSENSORS; APTAMERS; RISK;
D O I
10.1002/adma.201401829
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Organic field-effect transistor (OFET) sensors can meet the need for portable and real-time diagnostics. An electronic-readout enzyme-linked immunosorbent assay using OFETs for the detection of a panel of three biomarkers in complex media to create a pre-eclampsia prognostic is demonstrated, along with biodetection utilizing a fully inkjet-printed and flexible OFET to underscore our ability to produce disposable devices.
引用
收藏
页码:6138 / +
页数:8
相关论文
共 32 条
[1]   Longitudinal analysis of maternal plasma leptin concentrations during normal pregnancy and pre-eclampsia [J].
Anim-Nyame, N ;
Sooranna, SR ;
Steer, PJ ;
Johnson, MR .
HUMAN REPRODUCTION, 2000, 15 (09) :2033-2036
[2]   A longitudinal study of biochemical variables in women at risk of preeclampsia [J].
Chappell, LC ;
Seed, PT ;
Briley, A ;
Kelly, FJ ;
Hunt, BJ ;
Charnock-Jones, DS ;
Mallet, AI ;
Poston, L .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2002, 187 (01) :127-136
[3]   A SYSTEM FOR THE SEPARATION OF THE COMPONENTS OF HUMAN BLOOD - QUANTITATIVE PROCEDURES FOR THE SEPARATION OF THE PROTEIN COMPONENTS OF HUMAN PLASMA [J].
COHN, EJ ;
GURD, FRN ;
SURGENOR, DM ;
BARNES, BA ;
BROWN, RK ;
DEROUAUX, G ;
GILLESPIE, JM ;
KAHNT, FW ;
LEVER, WF ;
LIU, CH ;
MITTELMAN, D ;
MOUTON, RF ;
SCHMID, K ;
UROMA, E .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1950, 72 (01) :465-474
[4]  
El-Sherbeny G. A., 2005, International Journal of Agriculture and Biology, V7, P953
[5]   Enhanced Sensing of Nucleic Acids with Silicon Nanowire Field Effect Transistor Biosensors [J].
Gao, Anran ;
Lu, Na ;
Wang, Yuchen ;
Dai, Pengfei ;
Li, Tie ;
Gao, Xiuli ;
Wang, Yuelin ;
Fan, Chunhai .
NANO LETTERS, 2012, 12 (10) :5262-5268
[6]   Drivers of biodiagnostic development [J].
Giljohann, David A. ;
Mirkin, Chad A. .
NATURE, 2009, 462 (7272) :461-464
[7]   25th Anniversary Article: The Evolution of Electronic Skin (E-Skin): A Brief History, Design Considerations, and Recent Progress [J].
Hammock, Mallory L. ;
Chortos, Alex ;
Tee, Benjamin C-K ;
Tok, Jeffrey B-H ;
Bao, Zhenan .
ADVANCED MATERIALS, 2013, 25 (42) :5997-6037
[8]   Investigation of Protein Detection Parameters Using Nanofunctionalized Organic Field-Effect Transistors [J].
Hammock, Mallory L. ;
Knopfmacher, Oren ;
Naab, Benjamin D. ;
Tok, Jeffrey B. -H. ;
Bao, Zhenan .
ACS NANO, 2013, 7 (05) :3970-3980
[9]   Organic Transistors with Ordered Nanoparticle Arrays as a Tailorable Platform for Selective, In Situ Detection [J].
Hammock, Mallory L. ;
Sokolov, Anatoliy N. ;
Stoltenberg, Randall M. ;
Naab, Benjamin D. ;
Bao, Zhenan .
ACS NANO, 2012, 6 (04) :3100-3108
[10]   Mining the plasma proteome for cancer biomarkers [J].
Hanash, Samir M. ;
Pitteri, Sharon J. ;
Faca, Vitor M. .
NATURE, 2008, 452 (7187) :571-579