Cap-Independent Translation in Hematological Malignancies

被引：6

作者：

Horvilleur, Emilie ^{[1
]}

Wilson, Lindsay A. ^{[1
]}

Bastide, Amandine ^{[1
]}

Pineiro, David ^{[1
]}

Poeyry, Tuija A. A. ^{[1
]}

Willis, Anne E. ^{[1
]}

机构：

[1] MRC, Toxicol Unit, Leicester, Leics, England

来源：

FRONTIERS IN ONCOLOGY | 2015年 / 5卷

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

leukemia; lymphoma; myeloma; IRES; cap-independent; translation; INTERNAL RIBOSOME ENTRY; CHRONIC LYMPHOCYTIC-LEUKEMIA; RNA-BINDING PROTEINS; INITIATION-FACTOR; 4E; GROWTH-FACTOR; C-MYC; MULTIPLE-MYELOMA; MESSENGER-RNA; DRUG-RESISTANCE; HEMATOPOIETIC STEM;

D O I：

10.3389/fonc.2015.00293

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hematological malignancies are a heterogeneous group of diseases deriving from blood cells progenitors. Although many genes involved in blood cancers contain internal ribosome entry sites (IRESes), there has been only few studies focusing on the role of cap-independent translation in leukemia and lymphomas. Expression of IRES trans-acting factors can also be altered, and interestingly, BCL-ABL1 fusion protein expressed from "Philadelphia" chromosome, found in some types of leukemia, regulates several of them. A mechanism involving c-Myc IRES and cap-independent translation and leading to resistance to chemotherapy in multiple myeloma emphasize the contribution of cap-independent translation in blood cancers and the need for more work to be done to clarify the roles of known IRESes in pathology and response to chemotherapeutics.

引用

页数：7

共 98 条

[1] Maintenance of the plasma cell pool is independent of memory B cells [J].