Association between aggregative adherence fimbriae types including putative new variants and virulence-related genes and clump formation among aggR-positive Escherichia coli strains isolated in Thailand and Japan

被引：13

作者：

Ito, Kenitiro ^{[1
]}

Matsushita, Shigeru ^{[2
]}

Yamazaki, Mitsugu ^{[3
]}

Moriya, Kazuo ^{[4
]}

Kurazono, Takayuki ^{[5
]}

Hiruta, Noriaki ^{[6
]}

Narimatsu, Hiroshi ^{[7
]}

Ueno, Nobuhiro ^{[8
]}

Isobe, Junko ^{[9
]}

Yatsuyanagi, Jun ^{[10
]}

Kumagai, Norimichi ^{[11
]}

Hashimoto, Michiko ^{[11
]}

Ratchtrachenchai, Orn-Anong ^{[12
]}

机构：

[1] Natl Inst Infect Dis, Dept Bacteriol 1, Shinjuku Ku, Tokyo 1628640, Japan

[2] Tokyo Metropolitan Inst Publ Hlth, Shinjuku Ku, Tokyo 1690073, Japan

[3] Aichi Prefectural Inst Publ Hlth, Kita Ku, Nagoya, Aichi 4628576, Japan

[4] Saga Prefectural Ctr Publ Hlth & Pharmaceut Res, Saga 8490925, Japan

[5] Saitama Inst Publ Hlth, Saitama 3380824, Japan

[6] Yokosuka Inst Publ Hlth, Yokosuka, Kanagawa 2380006, Japan

[7] Oita Prefectural Inst Hlth & Environm, Oita 8701117, Japan

[8] Kagoshima Prefectural Inst Environm Res & Publ Hl, Kagoshima 8920836, Japan

[9] Toyama Inst Hlth, Imizu, Toyama 9390363, Japan

[10] Akita Prefectural Inst Publ Hlth, Akita 0100874, Japan

[11] Chubu Airport Quarantine Branch, Tokoname, Aichi 4790881, Japan

[12] Natl Inst Hlth, Dept Med Sci, A Muang 11000, Nonthaburi, Thailand

来源：

MICROBIOLOGY AND IMMUNOLOGY | 2014年 / 58卷 / 08期

关键词：

aggregative adherence (AA); aggregative adherence fimbriae (AAF) type; aggR-positive Escherichia coli; toxin gene; CHILDREN; IDENTIFICATION; DIARRHEA; PATHOGENESIS; OUTBREAK; FAMILY;

D O I：

10.1111/1348-0421.12173

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Enteroaggregative Escherichia coli (EAggEC) are an important cause of diarrhea. Four types of AAF have been identified; however, their prevalence and association with virulence properties remain unclear. E. coli strains carrying the aggR gene as EAggEC that were isolated in Japan and Thailand (n = 90) were examined for AAF subunit genes, two toxin genes (pet/astA), and clump formation. The most prevalent AAF gene was hdaA (28%), followed by aafA (20%), aggA (12%), and agg3A (4%), as well as a putative new AAF sequence (25.6%). Retention status of the toxin genes and intensities of clump formation appeared to vary according to the AAF type.

引用

页码：467 / 473

页数：7

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