A real-world, cross-sectional, community survey of symptoms and health-related quality of life of adults with acute myeloid leukemia

被引:11
作者
Mamolo, Carla M. [1 ]
Cappelleri, Joseph C. [1 ]
Hoang, Caroline J. [2 ]
Kim, Ruth [2 ]
Hadfield, Anna [3 ]
Middleton, Chloe [3 ]
Rider, Alex [3 ]
Walter, Roland B. [4 ]
机构
[1] Pfizer Inc, Groton, CT 06340 USA
[2] Pfizer Inc, New York, NY 10017 USA
[3] Adelphi Real World, Macclesfield SK10 5JB, Cheshire, England
[4] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA
关键词
acute myeloid leukemia; chemotherapy; clinical practice; community setting; quality of life; real-world; PATIENT-REPORTED OUTCOMES; FUNCTIONAL ASSESSMENT; CANCER-THERAPY; OLDER-ADULTS; DISEASE; COMORBIDITY; POPULATION; MANAGEMENT; DIAGNOSIS; VALIDITY;
D O I
10.2217/fon-2018-0842
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Aim: We used Adelphi Real World Disease-Specific Programme data to characterize adults with newly diagnosed or relapsed/refractory de novo acute myeloid leukemia (AML). Materials & methods: Community-practice hematologists/oncologists completed patient record forms for their regular AML patients. Patients were invited to complete patient self-completion forms including 3-Level EuroQol 5-Dimensions (EQ-5D-3L) and Functional Assessment of Cancer Therapy-Leukemia (FACT-Leu) questionnaires. Results: Physicians provided patient record forms for 389 patients (339 newly diagnosed, 50 relapsed/refractory); 68 patients completed patient self-completion forms. Mean EQ-5D visual-analog scale and index and FACT-General scores were significantly lower than US population norms (p<0.0001); health-related quality of life (HRQoL) scores were generally lower than 11 other cancers. Conclusion: HRQoL impairment is grave in AML. Efforts are needed to improve HRQoL in affected patients.
引用
收藏
页码:1895 / 1910
页数:16
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