Monotherapy Activity with the First CD20-Targeted Immunotoxin, MT-3724, in Subjects with Relapsed/Refractory (R/R) Diffuse Large B-Cell Lymphoma (DLBCL)

被引：2
|
作者：
Hamlin, Paul A. [1 ]
Musteata, Vasile [2 ]
Zodelava, Mamia [3 ]
Park, Steven I. [4 ]
Burnett, Christine [5 ]
Dabovic, Kristina [5 ]
Williams, Eric T. [5 ]
Higgins, Jack P. [5 ]
Persky, Daniel O. [6 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, David H Koch Ctr Canc Care, 1275 York Ave, New York, NY 10021 USA
[2] Arensia EM, Inst Oncol, Dept Hematol, Kishinev, Moldova
[3] LLC ARENSIA Exploratory Med, Tbilisi, Georgia
[4] Levine Canc Inst, Dept Hematol Oncol & Blood Disorders, Charlotte, NC USA
[5] Mol Templates Inc, Austin, TX USA
[6] Univ Arizona, Div Hematol Oncol, Tucson, AZ USA
来源：
BLOOD | 2019年 / 134卷
关键词：
D O I：
10.1182/blood-2019-129243
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
4098
引用
收藏
页数：3
相关论文
共 50 条
  • [1] Data from the First CD20-Targeted Immunotoxin, MT-3724, in a Phase I/Ib Study in Relapsed/Refractory (R/R) Non-Hodgkin's B-Cell Lymphoma (NHL)
    Hamlin, Paul A., Jr.
    Fanale, Michelle A.
    Park, Steven I.
    Valacer, David J.
    Higgins, Jack
    Younes, Anas
    BLOOD, 2016, 128 (22)
  • [2] Phase I/lb study of the novel CD20-targeted immunotoxin MT-3724 in relapsed/refractory non-Hodgkin's B-cell lymphoma
    Fanale, Michelle A.
    Hamlin, Paul A.
    Diefenbach, Catherine S.
    Park, Steven I.
    Valacer, David J.
    Higgins, Jack P.
    Younes, Anas
    CANCER RESEARCH, 2016, 76
  • [3] A Phase 2 Study of MT-3724 to Evaluate Safety, Pharmacodynamics and Efficacy of MT-3724 for the Treatment of Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma
    Persky, Daniel O.
    Musteata, Vasile
    Zodelava, Mamia
    Perekhrestenko, Tetiana
    Diaz, Adolfo E.
    Guthrie, Troy H., Jr.
    Strack, Thomas
    Burnett, Christine
    Wilson, Sarah
    Baetz, Tara
    BLOOD, 2019, 134
  • [4] Acalabrutinib monotherapy in patients (pts) with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL).
    Dyer, Martin J. S.
    De Vos, Sven
    Ruan, Jia
    Flowers, Christopher
    Maddocks, Kami J.
    Rule, Simon
    Hamdy, Ahmed M.
    Izumi, Raquel
    Slatter, J. Greg
    Cheung, Jean
    Frigualt, Melanie M.
    Wei, Helen
    Mourya, Sanchita
    Hunder, Naomi N. H.
    Fowler, Nathan Hale
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
  • [5] Safety and efficacy of anti-CD20 immunotoxin MT-3724 in relapsed/refractory (R/R) B-cell non-Hodgkin lymphoma (NHL) in a phase I study.
    Fanale, Michelle A.
    Hamlin, Paul A.
    Park, Steven I.
    Persky, Daniel Oscar
    Higgins, Jack P.
    Burnett, Christine
    Dabovic, Kristina
    Poma, Eric
    Sarapa, Nenad
    Younes, Anas
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
  • [6] Maximum Tolerated Dose (MTD) and Safety Profile from Phase I Study of MT-3724 (CD20 targeted immunotoxin) in Relapsed/Refractory (R/R) Non-Hodgkin B-Cell Lymphoma (NHL)
    Fanale, Michelle A.
    Park, Steven I.
    Valacer, David J.
    Higgins, Jack
    Sloan, John Mark
    Younes, Anas
    Hamlin, Paul A.
    BLOOD, 2017, 130
  • [7] Total Cost of Care in Relapsed/Refractory (R/R) Diffuse Large B-Cell Lymphoma (DLBCL)
    Gatwood, Justin
    Masaquel, Anthony
    Ross, Ryan
    Sheinson, Danny
    Hossain, Farah
    Li, Jia
    James, Cameron
    Fox, David
    BLOOD, 2022, 140 : 7906 - 7907
  • [8] Phase I/Ib Study of the Novel Immunotoxin MT-3724 in Relapsed/Refractory NonHodgkin's B-Cell Lymphoma (NHL)
    Hamlin, Paul A., Jr.
    Diefenbach, Catherine S.
    Valacer, David J.
    Higgins, Jack
    Fanale, Michelle A.
    BLOOD, 2015, 126 (23)
  • [9] Interim evaluation of a targeted radiotherapeutic, CLR 131, in relapsed/refractory diffuse large B-cell lymphoma patients (R/R DLBCL)
    Longcor, J.
    Oliver, K.
    Friend, J.
    Callandar, N.
    ANNALS OF ONCOLOGY, 2019, 30 : 435 - 435
  • [10] Understanding the patient experience in follicular lymphoma (FL), relapsed/refractory FL (R/R FL), and relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL)
    Bell, Jill A.
    Cherepanov, Dasha
    Revicki, Dennis
    Speck, Rebecca M.
    Swett, Laura
    Stumpo, Kate
    Rong, Yuanxin
    Gordon, Leo I.
    QUALITY OF LIFE RESEARCH, 2019, 28 : S67 - S68
12345