A consensus epitope prediction approach identifies the breadth of murine TCD8+-cell responses to vaccinia virus

被引：424
作者：
Moutaftsi, Magdalini
Peters, Bjoern
Pasquetto, Valerie
Tscharke, David C.
Sidney, John
Bui, Huynh-Hoa
Grey, Howard
Sette, Alessandro
机构：
[1] La Jolla Inst Allergy & Immunol, San Diego, CA 92109 USA
[2] Queensland Inst Med Res, Div Infect Dis & Immunol, Herston, Qld 4006, Australia
来源：
NATURE BIOTECHNOLOGY | 2006年 / 24卷 / 07期
关键词：
D O I：
10.1038/nbt1215
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The value of predictive algorithms for identifying CD8+ T (TCD8+)-cell epitopes has not been adequately tested experimentally. Here we demonstrate that conventional bioinformatic methods predict the vast majority of TCD8+-cell epitopes derived from vaccinia virus WR strain (VACV-WR) in the H-2(b) mouse model. This approach reveals the breadth of T-cell responses to vaccinia, a widely studied murine viral infection model, and may provide a tool for developing comprehensive antigenic maps of any complex pathogen.
引用
收藏
页码：817 / 819
页数：3
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