Synthesis of pentacoordinate phosphorus haptens for catalytic antibody production. Bait and switch concept

被引：0

作者：

Moriarty, RM ^{[1
]}

Liu, KM ^{[1
]}

Tuladhar, SM ^{[1
]}

Guo, L ^{[1
]}

Condeiu, C ^{[1
]}

Tao, AP ^{[1
]}

Xu, W ^{[1
]}

Lenz, D ^{[1
]}

Brimfield, A ^{[1
]}

机构：

[1] UNIV ILLINOIS, DEPT CHEM, CHICAGO, IL 60607 USA

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1996年 / 109卷 / 1-4期

关键词：

D O I：

暂无

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Our objective is to obtain monoclonal antibodies which will catalyse the hydrolysis of phosphorus-based nerve agents. Our syntheses followed three strategies. The first was synthesis of stable pentacoordinate phosphoranes as haptens for the production of monoclonal catalytic antibodies based on the transition state for phosphonate hydrolysis. The second approach is based upon the potential addition of water to the phosphorus atom of a tetracoordinate fluorine containing phosphate to yield an intermediary pentacoordinate system. In the third approach the ''bait and switch'' concept was used.

引用

页码：237 / 240

页数：4

共 23 条

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[2]

BARNARD EA, 1974, PERIPHERAL NERVOUS S, P210

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