Obesity, weight loss, and influence on telomere length: New insights for personalized nutrition

被引:43
作者
Welendorf, Caroline [1 ]
Nicoletti, Carolina Ferreira [1 ]
de Souza Pinhel, Marcela Augusta [1 ,2 ]
Noronha, Natalia Yumi [1 ]
Faleiros de Paula, Bruna Morais [1 ]
Nonino, Carla Barbosa [1 ,3 ]
机构
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Ribeirao Preto, Brazil
[2] Sao Jose Rio Preto Med Sch, Dept Mol Biol, Lab Studies Biochem & Mol Biol, Rio De Janeiro, Brazil
[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Hlth Sci, Ribeirao Preto, Brazil
关键词
Telomere length; Obesity; Shelterin complex; Biomarker; Weight loss; Nutritional intervention; CARDIOVASCULAR RISK-FACTORS; OXIDATIVE STRESS; BARIATRIC SURGERY; ADIPOSE-TISSUE; TEA CATECHINS; LIFE-STYLE; ASSOCIATION; CANCER; DNA; BIOLOGY;
D O I
10.1016/j.nut.2019.05.002
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Telomeres are structures located at the ends of chromosomes associated with proteins, from the shelter in complex, which are responsible for the protection and preservation of the genetic material. The telomere length (TL) progressively decreases with each cell division, and recent evidence suggests that lifestyle can lead to telomere shortening. In individuals with obesity, excess adipose tissue plays a key role in inducing a chronic and systemic inflammatory state, which can cause TL shortening. Thus, the aim of the present review was to show the relationship between obesity and TL in addition to the possible risk factors for its shortening and how the different strategies for weight loss can modulate TL. As the crucial result, we can consider the association between TL and weight loss, and adiposity changes after different interventions, showing that TL may be used as a biomarker of responses to obesity treatment. (C) 2019 Elsevier Inc. All rights reserved.
引用
收藏
页码:115 / 121
页数:7
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