Resveratrol and cognitive decline: a clinician perspective

被引:44
作者
Cicero, Arrigo F. G. [1 ]
Ruscica, Massimiliano [2 ]
Banach, Maciej [3 ]
机构
[1] Univ Bologna, Dept Med & Surg Sci, Bologna, Italy
[2] Univ Milan, Dept Pharmacol & Bimol Sci, Milan, Italy
[3] Med Univ Lodz, Dept Hypertens, Lodz, Poland
关键词
clinical trials; cognitive function; neuroprotection; preclinical models; resveratrol; CEREBRAL-BLOOD-FLOW; ENDOTHELIAL FUNCTION; MEMORY PERFORMANCE; ALZHEIMERS-DISEASE; TRANS-RESVERATROL; DOUBLE-BLIND; PROTECTS; INFLAMMATION; METABOLISM; ACTIVATION;
D O I
10.5114/aoms.2019.85463
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Resveratrol (3,5,4'-trihydroxystilbene) belongs to a family of polyphenolic compounds known as stilbenes, particularly concentrated in grape and red wine. The aim of our review was to critically review the available evidence of resveratrol effects on brain function and its potential impact on therapy. In preclinical models of cognitive decline, resveratrol displays potent antioxidant activity by scavenging free radicals, reducing quinone reductase 2 activity and upregulating endogenous enzymes. Resveratrol also inhibits pro-inflammatory enzyme expression, reduces nuclear factor-kappa B activation and cytokine release. Treatment with resveratrol can affect multiple signaling pathway effectors involved in cell survival, programmed cell death and synaptic plasticity. Direct and/or indirect activation of the deacetylase sirtuins by resveratrol has also been suggested. In humans, clinical evidence derived from randomized clinical trials suggests that resveratrol is able to improve cerebral blood flow, cerebral vasodilator responsiveness to hypercapnia, some cognitive tests, perceived performances, and the A beta(40) plasma and cerebrospinal fluid level.
引用
收藏
页码:936 / 943
页数:8
相关论文
共 74 条
  • [1] Therapeutic role of sirtuins in neurodegenerative disease and their modulation by polyphenols
    Ajami, Marjan
    Pazoki-Toroudi, Hamidreza
    Amani, Hamed
    Nabavi, Seyed Fazel
    Braidy, Nady
    Vacca, Rosa Anna
    Atanasov, Atanas Georgiev
    Mocan, Andrei
    Nabavi, Seyed Mohammad
    [J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2017, 73 : 39 - 47
  • [2] Resveratrol treatment has neuroprotective effects and prevents cognitive impairment after chronic cerebral hypoperfusion
    Anastacio, Janine R.
    Netto, Carlos A.
    Castro, Cibele C.
    Sanches, Eduardo F.
    Ferreira, Daniele C.
    Noschang, Cristie
    Krolow, Rachel
    Dalmaz, Carla
    Pagnussat, Aline
    [J]. NEUROLOGICAL RESEARCH, 2014, 36 (07) : 627 - 633
  • [3] Mild cognitive decline. A position statement of the Cognitive Decline Group of the European Innovation Partnership for Active and Healthy Ageing (EIPAHA)
    Apostolo, Joao
    Holland, Carol
    O'Connell, Matthew D. L.
    Feeney, Joanne
    Tabares-Seisdedos, Rafael
    Tadros, George
    Campos, Elzbieta
    Santos, Nadine
    Robertson, Deirdre A.
    Marcucci, Maura
    Varela-Nieto, Isabel
    Crespo-Facorro, Benedicto
    Vieta, Eduard
    Navarro-Pardo, Esperanza
    Selva-Vera, Gabriel
    Balanza-Martinez, Vicent
    Cano, Antonio
    [J]. MATURITAS, 2016, 83 : 83 - 93
  • [4] Intensive LDL-cholesterol lowering therapy and neurocognitive function
    Banach, Maciej
    Rizzo, Manfredi
    Nikolic, Dragana
    Howard, George
    Howard, VirginiaJ.
    Mikhailidis, DimitriP.
    [J]. PHARMACOLOGY & THERAPEUTICS, 2017, 170 : 181 - 191
  • [5] Neuroprotective action of resveratrol
    Bastianetto, Stephane
    Menard, Caroline
    Quirion, Remi
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2015, 1852 (06): : 1195 - 1201
  • [6] Resveratrol inhibits nitric oxide and TNF-α production by lipopolysaccharide-activated microglia
    Bi, XL
    Yang, JY
    Dong, YX
    Wang, JM
    Cui, YH
    Ikeshima, T
    Zhao, YQ
    Wu, CF
    [J]. INTERNATIONAL IMMUNOPHARMACOLOGY, 2005, 5 (01) : 185 - 193
  • [7] Neuropsychiatric symptoms and faster progression of cognitive impairments as predictors of risk of conversion of mild cognitive impairment to dementia
    Bidzan, Mariola
    Bidzan, Leszek
    Bidzan-Bluma, Ilona
    [J]. ARCHIVES OF MEDICAL SCIENCE, 2017, 13 (05) : 1168 - 1177
  • [8] Nanoparticle formulations to enhance tumor targeting of poorly soluble polyphenols with potential anticancer properties
    Bonferoni, Maria Cristina
    Rossi, Silvia
    Sandri, Giuseppina
    Ferrari, Franca
    [J]. SEMINARS IN CANCER BIOLOGY, 2017, 46 : 205 - 214
  • [9] Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia
    Candelario-Jalil, Eduardo
    de Oliveira, Antonio C. Pinheiro
    Graef, Sybille
    Bhatia, Harsharan S.
    Huell, Michael
    Munoz, Eduardo
    Fiebich, Bernd L.
    [J]. JOURNAL OF NEUROINFLAMMATION, 2007, 4 (1)
  • [10] AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
    Canto, Carles
    Gerhart-Hines, Zachary
    Feige, Jerome N.
    Lagouge, Marie
    Noriega, Lilia
    Milne, Jill C.
    Elliott, Peter J.
    Puigserver, Pere
    Auwerx, Johan
    [J]. NATURE, 2009, 458 (7241) : 1056 - U140