1,3-Diarylcycloalkanopyrazoles and diphenyl hydrazides as selective inhibitors of cyclooxygenase-2

被引：73

作者：

Sui, ZH ^{[1
]}

Guan, JH ^{[1
]}

Ferro, MP ^{[1
]}

McCoy, K ^{[1
]}

Wachter, MP ^{[1
]}

Murray, WV ^{[1
]}

Singer, M ^{[1
]}

Steber, M ^{[1
]}

Ritchie, DM ^{[1
]}

Argentieri, DC ^{[1
]}

机构：

[1] RW Johnson Pharmaceut Res Inst, Raritan, NJ 08869 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(00)00041-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel 1,3-diarylcycloalkanopyrazoles 1, and diphenyl hydrazides 2 were identified as selective inhibitors of cyclooxygenase-2. The 1,3-diaryl substitution pattern of the pyrazole ring in 1 differentiates these compounds from most of the known selective COX-2 inhibitors that contain two aryl rings at the adjacent positions on a heterocyclic or a phenyl ring. Similarly, the two phenyl rings in 2 are also separated by three atoms. SAR of both phenyl rings in 1 and 2, and the aliphatic ring in 1 will be discussed. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：601 / 604

页数：4

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