The Complexity of PRC2 Subcomplexes

被引：168

作者：

van Mierlo, Guido ^{[1
,2
]}

Veenstra, Gert Jan C. ^{[3
]}

Vermeulen, Michiel ^{[1
,2
]}

Marks, Hendrik ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, RIMLS, Dept Mol Biol, NL-6525 GA Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, RIMLS, Dept Mol Biol, Oncode Inst, NL-6525 GA Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Radboud Inst Mol Life Sci, Dept Mol Dev Biol, Fac Sci, NL-6500 HB Nijmegen, Netherlands

来源：

TRENDS IN CELL BIOLOGY | 2019年 / 29卷 / 08期

关键词：

HISTONE METHYLTRANSFERASE ACTIVITY; EMBRYONIC STEM-CELLS; NUCLEOSOME-BINDING; ENZYMATIC-ACTIVITY; H3K27; METHYLATION; POLYCOMB PROTEIN; GROUND-STATE; DNA-BINDING; GENE; JARID2;

D O I：

10.1016/j.tcb.2019.05.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Polycomb repressive complex 2 (PRC2) is a multisubunit protein complex essential for the development of multicellular organisms. Recruitment of PRC2 to target genes, followed by deposition and propagation of its catalytic product histone H3 lysine 27 trimethylation (H3K27me3), are key to the spatiotemporal control of developmental gene expression. Recent breakthrough studies have uncovered unexpected roles for substoichiometric PRC2 subunits in these processes. Here, we elaborate on how the facultative PRC2 subunits regulate catalytic activity, locus-specific PRC2 binding, and propagation of H3K27me3, and how this affects chromatin structure, gene expression, and cell fate.

引用

页码：660 / 671

页数：12

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