Treatment of alloimmune neonatal neutropenia with granulocyte colony-stimulating factor (G-CSF):: a report of two new cases

被引：4

作者：

Bédu, A

Rohrlich, P

Farnoux, C

Duval, M

Fenneteau, O

Boissinot, C

Pinquier, D

Cartron, J

Vilmer, E

Aujard, Y

机构：

[1] Hop Robert Debre, Serv Neonatol, F-75019 Paris, France

[2] Hop Robert Debre, ETS AP HP Site Transfusionnel, F-75019 Paris, France

[3] Hop Robert Debre, Serv Hematol Pediat, F-75019 Paris, France

[4] Hop Robert Debre, Serv Hematol Biol, F-75019 Paris, France

[5] Hop Robert Debre, Serv Gynecol Obstet, F-75019 Paris, France

[6] Hop Bicetre, ETS AP HP Site Transfusionnel, F-94275 Le Kremlin Bicetre, France

来源：

ARCHIVES DE PEDIATRIE | 1999年 / 6卷 / 12期

关键词：

infant; newborn; agranulocytosis; immune complex disease; G-CSF;

D O I：

10.1016/S0929-693X(00)88892-2

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Alloimmune neonatal neutropenia is a rare event. Usually asymptomatic, if may however in some cases result in a severe sepsis. Treatment with recombinant granulocyte colony-stimulating factor (G-CSF) has been recently proposed Case reports. - We report two new cases in infected newborns of a successful treatment of alloimmune neonatal neutropenia with G-CSF, resulting in complete neutrophil recovery in less than 72 hours. Moreover, the treatment was well tolerated Conclusion. - The analysis of these two cases and of those previously reported indicates that G-CSF represents the first-choice treatment in this affection when infectious signs are present in the neonate. (C) 1999 Editions scientifiques et medicales Elsevier SAS.

引用

页码：1297 / 1301

页数：5

共 17 条

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[2]

BEDU A, 1995, J PEDIATR-US, V127, P508, DOI 10.1016/S0022-3476(95)70101-X

[3] LONG-TERM SAFETY OF TREATMENT WITH RECOMBINANT HUMAN GRANULOCYTE-COLONY-STIMULATING FACTOR (R-METHUG-CSF) IN PATIENTS WITH SEVERE CONGENITAL NEUTROPENIAS [J].