Towards an individualised target concentration of adalimumab in rheumatoid arthritis

被引:25
作者
Ducourau, Emilie [1 ,2 ]
Ternant, David [1 ,3 ]
Lequerre, Thierry [4 ,5 ,6 ]
Fuzibet, Piera [1 ,2 ]
Le Loet, Xavier [4 ,5 ,6 ]
Watier, Herve [1 ,7 ]
Goupille, Philippe [1 ,2 ]
Paintaud, Gilles [1 ,3 ]
Vittecoq, Olivier [4 ,5 ,6 ]
Mulleman, Denis [1 ,2 ]
机构
[1] Univ Tours, CNRS, UMR 7292, Tours, France
[2] CHRU Tours, Serv Rhumatol, F-37044 Tours 9, France
[3] CHRU Tours, Lab Pharmacol Toxicol, F-37044 Tours 9, France
[4] Univ Rouen, INSERM, U905, Rouen, France
[5] CIC CRB0204, Rouen, France
[6] CHRU Rouen, Serv Rhumatol, Rouen, France
[7] CHRU Tours, Immunol Lab, F-37044 Tours 9, France
关键词
ANTIBODIES;
D O I
10.1136/annrheumdis-2013-204971
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1427 / 1428
页数:2
相关论文
共 6 条
[1]   Disease activity early in the course of treatment predicts response to therapy after one year in rheumatoid arthritis patients [J].
Aletaha, Daniel ;
Funovits, Julia ;
Keystone, Edward C. ;
Smolen, Josef S. .
ARTHRITIS AND RHEUMATISM, 2007, 56 (10) :3226-3235
[2]   Clinical response to adalimumab: relationship to anti-adalimumab antibodies and serum adalimumab concentrations in rheumatoid arthritis [J].
Bartelds, Geertje M. ;
Wijbrandts, Carla A. ;
Nurmohamed, Michael T. ;
Stapel, Steven ;
Lems, Willem F. ;
Aarden, Lucien ;
Dijkmans, Ben A. C. ;
Tak, Paul Peter ;
Wolbink, Gerrit Jan .
ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 (07) :921-926
[3]   Number and phenotype of rheumatoid arthritis patients' CD4+CD25hi regulatory T cells are not affected by adalimumab or etanercept [J].
Blache, Celine ;
Lequerre, Thierry ;
Roucheux, Arnaud ;
Beutheu, Stephanie ;
Dedreux, Ingrid ;
Jacquot, Serge ;
Le Loet, Xavier ;
Boyer, Olivier ;
Vittecoq, Olivier .
RHEUMATOLOGY, 2011, 50 (10) :1814-1822
[4]   Fitting Emax models to clinical trial dose-response data [J].
Kirby, Simon ;
Brain, Phil ;
Jones, Byron .
PHARMACEUTICAL STATISTICS, 2011, 10 (02) :143-149
[5]   Should anti-TNF-α drug levels and/or anti-drug antibodies be assayed in patients treated for rheumatoid arthritis? [J].
Mulleman, Denis ;
Ducourau, Emilie ;
Paintaud, Gilles ;
Ternant, David ;
Watier, Herve ;
Goupille, Philippe .
JOINT BONE SPINE, 2012, 79 (02) :109-112
[6]   Key findings towards optimising adalimumab treatment: the concentration-effect curve [J].
Pouw, Mieke F. ;
Krieckaert, Charlotte L. ;
Nurmohamed, Michael T. ;
van der Kleij, Desiree ;
Aarden, Lucien ;
Rispens, Theo ;
Wolbink, Gertjan .
ANNALS OF THE RHEUMATIC DISEASES, 2015, 74 (03) :513-518