Interferons: between structure and function

被引：27
作者：
Bandurska, Katarzyna [1 ]
Krol, Izabela [1 ]
Myga-Nowak, Magdalena [1 ]
机构：
[1] Akad Jana Dlugosza Czestochowie, Inst Chem Ochrony Srodowiska & Biotechnol, Zaklad Mikrobiol & Biotechnol, PL-42200 Czestochowa, Poland
来源：
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ | 2014年 / 68卷
关键词：
interferons type I; II; III; interferon receptors; antiviral protection; SINGLE NUCLEOTIDE POLYMORPHISM; IFN-GAMMA PROMOTER; I-INTERFERON; CRYSTAL-STRUCTURE; ALPHA-INTERFERON; LEUKOCYTE INTERFERON; ANGSTROM RESOLUTION; RECEPTOR COMPLEX; BLOOD LEUKOCYTES; MESSENGER-RNA;
D O I：
10.5604/17322693.1101229
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Interferons are a family of proteins that are released by a variety of cells in response to infections caused by viruses. Currently, we distinguish three types of interferons. They are classified based on the nucleotide sequence, interaction with specific receptors, chromosomal location, structure and physicochemical properties. The following interferons are classified as type I: alpha, beta, omega, kappa, epsilon, zeta, tau ,delta, nu They are recognized and bound by a receptor formed by two peptides, IFN-alpha R1 and IFN-alpha R2. Representative of type II interferons is interferon-gamma It binds to a receptor composed of chains IFNGR-1 and IFNGR-2. The recently classified type III interferons comprise IFN-lambda 1, IFN-lambda 2, and IFN-lambda 3. They act on receptors formed by lambda R1 IFN-and IL-10R2 subunits. A high level of antiviral protection is achieved by IFN-alpha, IFN-beta and IFN-lambda Antiviral activity
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页码：428 / 440
页数：13
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