Cell Systems to Investigate the Impact of Polyphenols on Cardiovascular Health

被引：35

作者：

Grootaert, Charlotte ^{[1
]}

Kamiloglu, Senem ^{[1
,2
]}

Capanoglu, Esra ^{[2
]}

Van Camp, John ^{[1
]}

机构：

[1] Univ Ghent, Fac Biosci Engn, Dept Food Safety & Food Qual, Lab Food Chem & Human Nutr, B-9000 Ghent 653, Belgium

[2] Istanbul Tech Univ, Fac Chem & Met Engn, Dept Food Engn, TR-34469 Istanbul, Turkey

来源：

NUTRIENTS | 2015年 / 7卷 / 11期

基金：

欧盟第七框架计划;

关键词：

co-culture; cytokine; endothelium; intestine; liver; GREEN TEA POLYPHENOL; NF-KAPPA-B; NECROSIS-FACTOR-ALPHA; INDUCED LIPID-ACCUMULATION; INDUCED HEPATIC STEATOSIS; ACTIVATED PROTEIN-KINASE; INTESTINAL CACO-2 CELLS; BLOOD MONONUCLEAR-CELLS; LOW-GRADE INFLAMMATION; RED WINE CONSUMPTION;

D O I：

10.3390/nu7115462

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Polyphenols are a diverse group of micronutrients from plant origin that may serve as antioxidants and that contribute to human health in general. More specifically, many research groups have investigated their protective effect against cardiovascular diseases in several animal studies and human trials. Yet, because of the excessive processing of the polyphenol structure by human cells and the residing intestinal microbial community, which results in a large variability between the test subjects, the exact mechanisms of their protective effects are still under investigation. To this end, simplified cell culture systems have been used to decrease the inter-individual variability in mechanistic studies. In this review, we will discuss the different cell culture models that have been used so far for polyphenol research in the context of cardiovascular diseases. We will also review the current trends in cell culture research, including co-culture methodologies. Finally, we will discuss the potential of these advanced models to screen for cardiovascular effects of the large pool of bioactive polyphenols present in foods and their metabolites.

引用

页码：9229 / 9255

页数：27

共 233 条

[51]

Forbes-Hernandez T. Y., 2015, CRIT REV FOOD SCI NU, DOI [10. 1080/10408398. 2015. 1051919 26357900, DOI 10.1080/10408398]

[52] ESTABLISHMENT OF A HUMAN CELL-LINE AFTER TRANSFORMATION BY A PLASMID CONTAINING THE EARLY REGION OF THE SV40 GENOME [J].