Bone marrow-derived myofibroblasts promote colon tumorigenesis through the IL-6/JAK2/STAT3 pathway

被引：34

作者：

Zhu, Liming ^{[1
,2
]}

Cheng, Xiaojiao ^{[1
]}

Ding, Yanfei ^{[1
]}

Shi, Jindong ^{[2
]}

Jin, Huanyu ^{[2
]}

Wang, Hong ^{[2
]}

Wu, Yunlin ^{[1
]}

Ye, Jing ^{[3
]}

Lu, Yiming ^{[3
]}

Wang, Timothy C. ^{[4
]}

Yang, Chung S. ^{[2
]}

Tu, Shui Ping ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Gastroenterol, Shanghai 200025, Peoples R China

[2] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Piscataway, NJ 08854 USA

[3] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Shanghai 200025, Peoples R China

[4] Columbia Univ Coll Phys & Surg, Dept Med, New York, NY 10032 USA

来源：

CANCER LETTERS | 2014年 / 343卷 / 01期

关键词：

Bone marrow-derived myofibroblasts; Cancer stem cell; Colon cancer; IL-6; STAT3; EPITHELIAL-MESENCHYMAL TRANSITION; SERUM INTERLEUKIN-6 LEVELS; CANCER STEM-CELLS; TGF-BETA; STAT3; IL-6; FIBROBLASTS; INFLAMMATION; CARCINOMA; INVASION;

D O I：

10.1016/j.canlet.2013.09.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Bone marrow-derived myofibroblasts (BMFs) have been shown to promote tumor growth. Here, we found that BMFs or BMF conditioned medium (BMF-CM) induced cancer stem cell-like sphere formation of colon cancer cells. The co-cultured BMFs, but not co-cultured cancer cells, expressed higher levels of IL-6 than BMFs or cancer cells cultured alone. Anti-mouse IL-6 neutralizing antibody, JAK2 inhibitors and STAT3 knockdown in mouse cancer cells reduced BMF- and BMF-CM-induced sphere formation of colon cancer cells. When co-injected, BMFs significantly enhanced tumorigenesis of colon cancer cells in mice. Our results demonstrate that BMFs promote tumorigenesis via the activation of the IL-6/JAK2/STAT3 pathway. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：80 / 89

页数：10

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