Bone marrow-derived myofibroblasts promote colon tumorigenesis through the IL-6/JAK2/STAT3 pathway

被引：34
|
作者：
Zhu, Liming [1 ,2 ]
Cheng, Xiaojiao [1 ]
Ding, Yanfei [1 ]
Shi, Jindong [2 ]
Jin, Huanyu [2 ]
Wang, Hong [2 ]
Wu, Yunlin [1 ]
Ye, Jing [3 ]
Lu, Yiming [3 ]
Wang, Timothy C. [4 ]
Yang, Chung S. [2 ]
Tu, Shui Ping [1 ,2 ]
机构：
[1] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Gastroenterol, Shanghai 200025, Peoples R China
[2] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Piscataway, NJ 08854 USA
[3] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Shanghai 200025, Peoples R China
[4] Columbia Univ Coll Phys & Surg, Dept Med, New York, NY 10032 USA
来源：
CANCER LETTERS | 2014年 / 343卷 / 01期
关键词：
Bone marrow-derived myofibroblasts; Cancer stem cell; Colon cancer; IL-6; STAT3; EPITHELIAL-MESENCHYMAL TRANSITION; SERUM INTERLEUKIN-6 LEVELS; CANCER STEM-CELLS; TGF-BETA; STAT3; IL-6; FIBROBLASTS; INFLAMMATION; CARCINOMA; INVASION;
D O I：
10.1016/j.canlet.2013.09.017
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Bone marrow-derived myofibroblasts (BMFs) have been shown to promote tumor growth. Here, we found that BMFs or BMF conditioned medium (BMF-CM) induced cancer stem cell-like sphere formation of colon cancer cells. The co-cultured BMFs, but not co-cultured cancer cells, expressed higher levels of IL-6 than BMFs or cancer cells cultured alone. Anti-mouse IL-6 neutralizing antibody, JAK2 inhibitors and STAT3 knockdown in mouse cancer cells reduced BMF- and BMF-CM-induced sphere formation of colon cancer cells. When co-injected, BMFs significantly enhanced tumorigenesis of colon cancer cells in mice. Our results demonstrate that BMFs promote tumorigenesis via the activation of the IL-6/JAK2/STAT3 pathway. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：80 / 89
页数：10
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