DEVELOPMENT AND EVALUATION OF NIOSOMAL DRUG DELIVERY SYSTEM CONTAINING TRANEXAMIC ACID

The present study aimed to optimize the drug delivery of tranexamic acid from the niosomes by using different grades of surfactants and cholesterol at different molar concentrations in order to achieve prolonged release time and sustained release. Tranexamic acid is one of the most effective antifibrinolytic drugs used in the treatment of fibrinolysis. Niosomes are the novel vesicular drug delivery system by which we can achieve the constant plasma drug concentration for the extended period of time. The vesicles are prepared from nonionic surfactants and cholesterol by thin film hydration technique. Niosomes have been investigated in recent years due to their potential applications in the drug delivery of hydrophobic and hydrophilic drugs. Niosomal drug delivery systems offer an advantage over conventional delivery systems by delivering the drugs in a sustained manner to overcome some problems associated with conventional drug delivery such as insolubility, instability and low bioavailability. The prepared Tranexamic acid niosomes were evaluated for size, shape and morphology, percent drug entrapment, and stability studies. In-vitro drug release studies were performed and drug release kinetics was evaluated. From this study it was observed that the formulation TNF 9 shows satisfactory particle size 861.9 nm, entrapment efficiency 92.70 % and in-vitro drug release 79.49 % for the period of 24 hours. Thus the niosomal formulation could be promising delivery system for tranexamic acid with better antifibrinolytic activity, stability and sustained drug release profile.