Dysprosium-containing layered double hydroxides nanoparticles intercalated with biologically active species as an approach for theranostic systems

被引：14

作者：

Arratia-Quijada, Jenny ^{[1
]}

Sanchez Jimenez, Cecilia ^{[2
]}

Gurinov, Andrey ^{[3
,4
]}

Perez Centeno, Armando ^{[5
]}

Ceja Andrade, Israel ^{[5
]}

Carbajal Arizaga, Gregorio Guadalupe ^{[2
]}

机构：

[1] Univ Guadalajara, Ctr Univ Tonala, Dept Ciencias Salud, Tonala 48525, Jalisco, Mexico

[2] Univ Guadalajara, Dept Quim, Guadalajara 44430, Jalisco, Mexico

[3] St Petersburg State Univ, Res Resources Ctr Magnet Resonance, St Petersburg 198504, Russia

[4] King Abdullah Univ Sci & Technol, NMR Core Lab, Thuwal 239556900, Saudi Arabia

[5] Univ Guadalajara, Dept Fis, Guadalajara 44430, Jalisco, Mexico

来源：

MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS | 2016年 / 203卷

关键词：

Hydroxides; MRI; Contrast agent; Carrier; Drug; OXIDE NANOPARTICLES; CONTROLLED-RELEASE; IMAGING CONTRAST; FOLIC-ACID; AGENTS; TUMOR; SALTS; GD;

D O I：

10.1016/j.mseb.2015.10.004

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

A layered double hydroxide structure including dysprosium cations was prepared by co-precipitation. The nanoparticles showed a linear relationship with the reciprocal relaxation spin-lattice (T1) time of water protons which is reflected as contrast in aqueous suspensions analyzed by magnetic resonance imaging. The interlayer space of dysprosium containing LDH was successfully intercalated with folate, ibuprofen and gallate ions, which are key molecules for recognition of some cancer cells and treatment of diseases. The paramagnetic property of the dysprosium-containing LDH detected in this work beside the ability to transport drugs open up the opportunity to design theranostic materials in a single crystal phase with nanometric dimensions. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：7 / 12

页数：6

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