Characteristics of Group B Streptococcus Isolated from Infants with Invasive Infections: A Population-Based Study in Japan

被引：22

作者：

Chang, Bin ^{[1
]}

Wada, Akihito ^{[2
]}

Hosoya, Mitsuaki ^{[3
]}

Oishi, Tomohiro ^{[4
]}

Ishiwada, Naruhiko ^{[5
]}

Oda, Megumi ^{[6
]}

Sato, Tetsuya ^{[7
]}

Terauchi, Yoshihiko ^{[7
]}

Okada, Kenji ^{[8
]}

Nishi, Junichiro ^{[9
]}

Akeda, Hideki ^{[10
,11
]}

Kamiya, Hitoshi ^{[12
]}

Ohnishi, Makoto ^{[1
]}

Ihara, Toshiaki ^{[12
]}

机构：

[1] Natl Inst Infect Dis, Dept Bacteriol 1, Shinjuku Ku, Tokyo 1628640, Japan

[2] Yonaguni Jima Clin, Okinawa 9071801, Japan

[3] Fukushima Med Univ, Dept Pediat, Fukushima 9601295, Japan

[4] Niigata Univ, Dept Pediat, Niigata 9508510, Japan

[5] Chiba Univ Hosp, Div Control & Treatment Infect Dis, Chiba 2608670, Japan

[6] Okayama Univ Hosp, Dept Pediat Hematol Oncol, Okayama 7008558, Japan

[7] Kochi Univ, Dept Pediat, Kochi 7838505, Japan

[8] Fukuoka Dent Coll, Dept Pediat, Fukuoka 8140193, Japan

[9] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Microbiol, Kagoshima 8908544, Japan

[10] Okinawa Prefectural Nanbu Med Ctr, Okinawa 9011193, Japan

[11] Childrens Med Ctr, Okinawa 9011193, Japan

[12] Natl Mie Hosp, Tsu, Mie 5140125, Japan

来源：

JAPANESE JOURNAL OF INFECTIOUS DISEASES | 2014年 / 67卷 / 05期

关键词：

COLONIZING STRAINS; PREGNANT-WOMEN; UNITED-STATES; DISEASE; EPIDEMIOLOGY; AGALACTIAE; LINEAGES; VACCINE; ONSET;

D O I：

10.7883/yoken.67.356

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Group B Streptococcus (GBS) is one of the leading causes of neonatal bacterial infections. Population-based surveillance of GBS-related invasive diseases among newborns and infants from 10 prefectures in Japan was performed between 2007 and 2012. The characteristics of cases and isolated GBS are described in this study. The incidence rate of GBS-related invasive diseases was 0.13 per 1,000 live births. Analysis of GBS samples obtained from 60 invasive cases showed that the most frequent serotypes were III (48.3%), Ia (30.0%), and Ib (10.0%). All isolates were susceptible to penicillin G, ampicillin, cefotaxime, imipenem, and panipenem. However, 14, 2, and 7 isolates were resistant to erythromycin, clindamycin, and both erythromycin and clindamycin, respectively. Multilocus sequence typing revealed that GBS sequence type (ST) 23, ST 17, and ST335 caused higher incidences of meningitis. These data show that serotypes III, Ia, and Ib together caused more than 80% of invasive infections in Japanese infants, and that GBS strains are still susceptible to beta-lactam antibiotics.

引用

页码：356 / 360

页数：5

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