Total Synthesis of the α-Glucosidase Inhibitors Schulzeine A, B, and C and a Structural Revision of Schulzeine A

被引：40

作者：

Bowen, Edward G. ^{[1
]}

Wardrop, Duncan J. ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Chicago, IL 60607 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 17期

基金：

美国国家卫生研究院;

关键词：

DERIVATIVES;

D O I：

10.1021/ja9005755

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The enantioselective total synthesis of the potent a-glucosidase inhibitors schulzeine A, B, and C and a revision of the proposed C20' configuration of schulzeine A are reported. The central feature of our convergent route to this family of novel marine natural products is the preparation of the common benzo[a]quinolizidine subunit through a substrate-controlled, diastereoselective Pictet-Spengler cyclocondensation.

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页码：6062 / +

页数：3

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